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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 412348-60-8 Chemical Structure| 412348-60-8

Structure of 412348-60-8

Chemical Structure| 412348-60-8

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Product Details of [ 412348-60-8 ]

CAS No. :412348-60-8
Formula : C14H20BrN3O2
M.W : 342.23
SMILES Code : O=C(N1CCN(C2=CC(Br)=CN=C2)CC1)OC(C)(C)C
MDL No. :MFCD11872647

Safety of [ 412348-60-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 412348-60-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 412348-60-8 ]

[ 412348-60-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 625-92-3 ]
  • [ 224311-51-7 ]
  • [ 57260-71-6 ]
  • [ 412348-60-8 ]
YieldReaction ConditionsOperation in experiment
20% tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; ethyl acetate; Example 123A 4-(5-Bromo-pyridin-3-yl)-piperazine-1-carboxylic Acid Tert-Butyl Ester A solution of the 3,5-dibromo-pyridine (12.8 g, 68.8 mmol) and piperazine-1-carboxylic acid tert butyl ester (10 g, 42.4 mmol) in 200 mL of dioxane was treated with Pd2(dba)3 (5 g, 5.5 mmol), 2-(di-tbutyl-phosphino)biphenyl (4 g, 13.4 mmol), and sodium t-butoxide (7.2 g, 75 mmol). The reaction was heated to 95° C. for 8 h then cooled and filtered through celite. The mixture was evaporated and the residue was purified by flash column chromatography on silica gel, eluding with a solvent gradient of 1:4 ethyl acetate/hexane to 100percent ethyl acetate. Recovered 2.9 g of product (20percent). MS (ESI) m/z 344 (M+H)+.
 

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