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[ CAS No. 41337-81-9 ] {[proInfo.proName]}

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Chemical Structure| 41337-81-9
Chemical Structure| 41337-81-9
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Product Details of [ 41337-81-9 ]

CAS No. :41337-81-9 MDL No. :MFCD09750009
Formula : C9H11NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :CDFOARSBQKJGNL-UHFFFAOYSA-N
M.W : 181.19 Pubchem ID :10921141
Synonyms :

Safety of [ 41337-81-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 41337-81-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 41337-81-9 ]
  • Downstream synthetic route of [ 41337-81-9 ]

[ 41337-81-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 41337-81-9 ]
  • [ 1197-10-0 ]
YieldReaction ConditionsOperation in experiment
89%
Stage #1: With sodium hydroxide In methanol; water at 20℃; for 1 h;
Stage #2: With hydrogenchloride In methanol; water
6-Hydroxymethyl-pyridine-2-carboxylic acid ethylester (200 mg, 1.1 mmol) (J. Amer. Chem. Soc, 1982, 104,2251-2257) was dissolved in methanol (1 ml). Thereafter, therein 2N NAOH aqueous solution (1 ml) was slowly added dropwise, and the reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was acidified (pH=3) with 2N HC1. Solvent was concentrated under reduced pressure, then, dissolved in methanol and filtered. The filtrate was concentrated under reduced pressure to give 150 mg (yield: 89percent, white solid) of the target compound. 1H NMR (400MHZ, CD30D) : 55. 05 (s, 2H), 8.34 (d, J=8. OHZ, 1H), 8.47 (d, J=8. OHZ, 1H) 8.73 (d, J=8. OHz, 1H)
Reference: [1] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1994, vol. 49, # 8, p. 1127 - 1136
[2] Patent: WO2004/113281, 2004, A1, . Location in patent: Page 57
[3] Journal of the American Chemical Society, 1982, vol. 104, # 8, p. 2251 - 2257
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