Alternatived Products of [ 39640-51-2 ]
Product Details of [ 39640-51-2 ]
CAS No. : | 39640-51-2 |
MDL No. : | MFCD03427128 |
Formula : |
C9H11NO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | FMSXHQBTRLUYHP-UHFFFAOYSA-N |
M.W : |
165.19
|
Pubchem ID : | 564597 |
Synonyms : |
|
Application In Synthesis of [ 39640-51-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 39640-51-2 ]
- 1
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[ 1197-10-0 ]
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[ 20077-29-6 ]
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[ 39640-51-2 ]
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[ 41337-81-9 ]
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[ 287925-06-8 ]
- 2
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[ 39640-51-2 ]
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[ 65854-91-3 ]
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[ 1050202-94-2 ]
- 3
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[ 39640-51-2 ]
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[ 97278-44-9 ]
Yield | Reaction Conditions | Operation in experiment |
32% |
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 84℃; Heating / reflux; |
1 Intermediate 3: 6-(4-Iodo-phenoxymethyl)-pyridine-2-carboxylic acid ethyl ester
Step 1: 6-Bromomethyl-pyridine-2-carboxylic acid ethyl ester Finely ground N-bromo-succinimide (29.4 g, 165.2 mmol) was added in several portions to a solution of 6-methyl-pyridine-2-carboxylic acid ethyl ester (24.7 g, 150.0 mmol; available from Aldrich Chemical Company, Inc., Milwaukee, Wis.) in carbon tetrachloride (500 mL), and then benzoyl peroxide (100 mg, 0.4 mmol) was added. The mixture was heated at 84 degrees under nitrogen for approximately 40 h. Further portions of N-bromo-succinimide (14.8 g, 83.2 mmol) and then benzoyl peroxide (100 mg, 0.4 mmol) were added and heating was continued overnight. The reaction mixture was cooled to room temperature, filtered, evaporated, and purified by chromatography on silica gel using a Biotage system, eluding with 1:1 dichloromethane/hexane and dichloromethane to give 6-bromomethyl-pyridine-2-carboxylic acid ethyl ester (11.8 g, 32%) as a pale yellow oil. MS (MH+): 244/246. From HPLC, the purity was estimated at 85-90% and the material was used in the next step without further purification. |
|
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane for 14h; Heating / reflux; |
198
Example 198; A mixture of 6-methyl-pyridine-2-carboxylic acid ethyl ester (1.65g, 10 mmol), NBS (1.77g, 10 mmol), and benzoyl peroxide (100 mg) in carbon tetrachloride (20ml) was refluxed for 14 h. After cooling to room temperature, the reaction mixture was.partitioned between diethyl ether and water (120ml, 4: 1), organic layer was washed with water (2X20 ml), brine, dried (MgS04), filtered and concentrated to give 6-bromomethyl-pyridine-2- carboxylic acid ethyl ester (2.4 g) which was used without further purification. LCMS m/z: 245 (M+1)+. |
- 4
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[ 128-08-5 ]
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[ 39640-51-2 ]
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[ 97278-44-9 ]
Yield | Reaction Conditions | Operation in experiment |
40% |
In neat (no solvent) for 48h; Inert atmosphere; Schlenk technique; Reflux; |
|
- 5
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[ 39640-51-2 ]
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[ 115-70-8 ]
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N-(2-ethyl-1,3-dihydroxypropan-2-yl)-6-methylpicolinamide
[ No CAS ]