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Chemical Structure| 41373-36-8 Chemical Structure| 41373-36-8

Structure of 41373-36-8

Chemical Structure| 41373-36-8

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Product Details of [ 41373-36-8 ]

CAS No. :41373-36-8
Formula : C13H10N2O
M.W : 210.23
SMILES Code : NC1=CC=CC(C2=NC3=CC=CC=C3O2)=C1
MDL No. :MFCD00579110

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Application In Synthesis of [ 41373-36-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41373-36-8 ]

[ 41373-36-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 99586-31-9 ]
  • [ 41373-36-8 ]
YieldReaction ConditionsOperation in experiment
78.2% With Benzophenone imine; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); In toluene; at 110℃; 10.0 g (36.50 mmol) of the intermediate (32) in a 1 neck 1000 mL flask, 7.9 g (43.80 mmol) of benzophenone imine and 243 mL of toluene were added, followed by 1.1 g (1.82 mmol) of Pd (dba) 2, 2.3 g (3.65 mmol) of BINAP, and 35.7 g (109.40 mmol) of Cs2CO3. Stirred all day at 110; After the reaction was completed, the reaction mixture was cooled to room temperature, and the reaction product was passed through a celite pad using chloroform under reduced pressure, and then the solvent was removed by distillation under reduced pressure. The resulting compound was diluted in 182 mL of THF, acidified (pH 8) with saturated Na 2 CO 3 solution, extracted with chloroform, water was removed with MgSO 4, and the solvent was removed by distillation under reduced pressure. The obtained compound was slurryed with DCM and Hexane to give 5.9 g (yield: 78.2%) of a yellow solid compound (intermediate (33)).
  • 2
  • [ 99586-31-9 ]
  • [ 41373-36-8 ]
  • C39H24N4O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
60.9% With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate; In 5,5-dimethyl-1,3-cyclohexadiene; toluene; at 125 - 130℃; 1.8 g (8.56 mmol) of the intermediate (33), 6.1 g (22.30 mmol) of the intermediate (32) and 57 mL of Xylene were added to a one-neck 250 mL flask. 0.5 g (0.86 mmol) of Pd (dba) 2, 4.9 g (51.40 mmol) of sodium tert-butoxide and 0.7 g (1.71 mmol) of tri-tertbutylphospine (50 wt% in Toluene) were added and stirred at 125-130 C. throughout the day It was. After the reaction was completed, the mixture was cooled to room temperature, and the precipitated solid was filtered through Hexane to obtain a beige solid. The obtained compound was dissolved in hot chloroform and purified by SiO 2 column chromatography (Hot CHCl 3: EA = 50: 1). Slurry with CHCl 3 and Hexane gave 3.1 g (yield: 60.9%) of compound 2-25 (LT18-30-269) as a pale yellow solid.
 

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