Home Cart 0 Sign in  
X

[ CAS No. 4146-43-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
3d Animation Molecule Structure of 4146-43-4
Chemical Structure| 4146-43-4
Chemical Structure| 4146-43-4
Structure of 4146-43-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 4146-43-4 ]

Related Doc. of [ 4146-43-4 ]

Alternatived Products of [ 4146-43-4 ]

Product Details of [ 4146-43-4 ]

CAS No. :4146-43-4 MDL No. :MFCD00007613
Formula : C4H10N4O2 Boiling Point : -
Linear Structure Formula :- InChI Key :HCOMFAYPHBFMKU-UHFFFAOYSA-N
M.W : 146.15 Pubchem ID :72491
Synonyms :

Calculated chemistry of [ 4146-43-4 ]

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.5
Num. rotatable bonds : 5
Num. H-bond acceptors : 4.0
Num. H-bond donors : 4.0
Molar Refractivity : 32.76
TPSA : 110.24 Ų

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -9.16 cm/s

Lipophilicity

Log Po/w (iLOGP) : -0.42
Log Po/w (XLOGP3) : -2.77
Log Po/w (WLOGP) : -2.25
Log Po/w (MLOGP) : -1.37
Log Po/w (SILICOS-IT) : -2.36
Consensus Log Po/w : -1.83

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 3.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : 1.33
Solubility : 3120.0 mg/ml ; 21.3 mol/l
Class : Highly soluble
Log S (Ali) : 1.01
Solubility : 1490.0 mg/ml ; 10.2 mol/l
Class : Highly soluble
Log S (SILICOS-IT) : 0.05
Solubility : 164.0 mg/ml ; 1.12 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.55

Safety of [ 4146-43-4 ]

Signal Word:Danger Class:4.1
Precautionary Statements:P210-P240-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P370+P378-P403+P233-P501 UN#:1325
Hazard Statements:H228-H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 4146-43-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4146-43-4 ]

[ 4146-43-4 ] Synthesis Path-Downstream   1~88

  • 2
  • [ 620-02-0 ]
  • [ 4146-43-4 ]
  • [ 976-66-9 ]
  • 5
  • [ 67-47-0 ]
  • [ 4146-43-4 ]
  • succinic acid bis-(5-hydroxymethyl-furfurylidenehydrazide) [ No CAS ]
  • 6
  • [ 698-63-5 ]
  • [ 4146-43-4 ]
  • [ 94783-48-9 ]
  • 7
  • [ 120-57-0 ]
  • [ 4146-43-4 ]
  • succinic acid bis-piperonylidenehydrazide [ No CAS ]
  • 8
  • [ 4146-43-4 ]
  • [ 98198-08-4 ]
  • 9
  • [ 4146-43-4 ]
  • succinic acid dihydrazide; compound with hydrogen peroxide [ No CAS ]
  • 10
  • [ 4146-43-4 ]
  • [ 543-20-4 ]
  • 11
  • <i>N</i>,<i>N</i>'-bis-(3-ethoxycarbonyl-propionyl)-hydrazine [ No CAS ]
  • [ 4146-43-4 ]
  • 12
  • [ 4146-43-4 ]
  • [ 89-98-5 ]
  • succinic acid bis-(2-chloro-benzylidenehydrazide) [ No CAS ]
  • 13
  • [ 4146-43-4 ]
  • [ 10031-82-0 ]
  • [ 122725-82-0 ]
  • 14
  • [ 4146-43-4 ]
  • [ 76-83-5 ]
  • succinic acid bis-(<i>N</i>'-trityl-hydrazide) [ No CAS ]
  • 17
  • [ 4146-43-4 ]
  • [ 123-11-5 ]
  • [ 80728-98-9 ]
  • 18
  • [ 4146-43-4 ]
  • [ 553-97-9 ]
  • succinic acid bis-(3-methyl-4-oxo-cyclohexa-2,5-dienylidenehydrazide) [ No CAS ]
  • 20
  • [ 4146-43-4 ]
  • [ 121-33-5 ]
  • succinic acid bis-vanillylidenehydrazide [ No CAS ]
  • 21
  • [ 4146-43-4 ]
  • [ 75-07-0 ]
  • succinic acid bis-ethylidenehydrazide [ No CAS ]
  • 22
  • [ 4146-43-4 ]
  • [ 123-72-8 ]
  • succinic acid bis-butylidenehydrazide [ No CAS ]
  • 23
  • [ 4146-43-4 ]
  • [ 110-13-4 ]
  • hexane-2,5-dione-(3-hydrazinocarbonyl-propionylhydrazone)-[3-(1-methyl-4-oxo-pentylidenehydrazinocarbonyl)-propionylhydrazone] [ No CAS ]
Reference: [1],1944,vol. 2,p. 8
  • 26
  • [ 4146-43-4 ]
  • [ 431-03-8 ]
  • [ 109016-11-7 ]
  • 27
  • [ 4146-43-4 ]
  • [ 104-55-2 ]
  • succinic acid bis-cinnamylidenehydrazide [ No CAS ]
  • 28
  • [ 4146-43-4 ]
  • [ 98-86-2 ]
  • [ 99888-69-4 ]
  • 30
  • [ 4146-43-4 ]
  • [ 3019-18-9 ]
  • [ 101609-96-5 ]
  • 31
  • [ 4146-43-4 ]
  • [ 106-51-4 ]
  • succinic acid bis-(4-oxo-cyclohexa-2,5-dienylidenehydrazide) [ No CAS ]
  • 32
  • [ 123-25-1 ]
  • [ 4146-43-4 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; for 4h;Reflux; Succinoyldihydrazine was prepared by reacting diethyl succinate (10.0 g, 49.50 mmol) with hydrazine hydrate (5.50 g, 110.00 mmol) under reflux for 4 hrs and recrystallized from methanol.
With hydrazine hydrate; In ethanol; Ligand preparation involves two steps. In the frst step, it involved condensation of diethylsuccinate with hydrazine hydrate in 1:2.5 molar ratio in ethanol to give succinoyldihydrazide.In the second step, condensation of succinoyldihydrazide (2 g, 13.70 mmol) with2-hydroxy-1-benzaldehyde (3.68 g, 30.16 mmol) and 2-hydroxy-1-naphthaldehyde (5.19 g,30.16 mmol) gave the desired ligands H4slsch and H4npsch in moderate yield.
  • 33
  • [ 4146-43-4 ]
  • [ 2049-86-7 ]
  • <i>N</i>,<i>N</i>'-bis-(3,4-diethoxycarbonyl-2,5-dimethyl-pyrrol-1-yl)-succinamide [ No CAS ]
  • 34
  • [ 79-36-7 ]
  • [ 4146-43-4 ]
  • [ 15100-67-1 ]
  • 35
  • [ 233605-26-0 ]
  • [ 4146-43-4 ]
  • [ 4310-01-4 ]
  • 36
  • [ 110-15-6 ]
  • [ 4146-43-4 ]
  • 39
  • [ 4146-43-4 ]
  • [ 13292-22-3 ]
  • [ 51707-28-9 ]
  • 42
  • [ 4146-43-4 ]
  • 3-Oxo-13α-hydroxy-13,17-seco-androstansaeure-(17) [ No CAS ]
  • sym. Succinyldihydrazon d. 3-Oxo-13α-hydroxy-13,17-seco-androstansaeure-(17) [ No CAS ]
  • 44
  • [ 17511-68-1 ]
  • [ 4146-43-4 ]
  • 46
  • [ 4146-43-4 ]
  • [ 2131-64-8 ]
  • C22H30N8O2S2 [ No CAS ]
  • 47
  • [ 4146-43-4 ]
  • [ 98-60-2 ]
  • [ 30222-57-2 ]
  • 48
  • [ 4146-43-4 ]
  • [ 98-09-9 ]
  • [ 30222-56-1 ]
  • 49
  • [ 4146-43-4 ]
  • [ 98-59-9 ]
  • [ 30277-07-7 ]
  • 51
  • [ 4146-43-4 ]
  • [ 122-57-6 ]
  • [ 30277-09-9 ]
  • 56
  • [ 527-69-5 ]
  • [ 4146-43-4 ]
  • [ 132500-89-1 ]
  • 57
  • [ 5271-67-0 ]
  • [ 4146-43-4 ]
  • [ 132500-90-4 ]
  • 58
  • [ 4146-43-4 ]
  • [ 3282-30-2 ]
  • [ 132500-93-7 ]
  • 59
  • [ 4146-43-4 ]
  • [ 622-59-3 ]
  • [ 139004-29-8 ]
  • 60
  • [ 4146-43-4 ]
  • [ 98-88-4 ]
  • [ 56447-82-6 ]
  • 61
  • [ 4146-43-4 ]
  • [ 103-72-0 ]
  • [ 18670-38-7 ]
  • 62
  • [ 4146-43-4 ]
  • [ 100-07-2 ]
  • [ 132500-88-0 ]
  • 63
  • [ 4146-43-4 ]
  • [ 75-36-5 ]
  • [ 35658-21-0 ]
  • 64
  • [ 4146-43-4 ]
  • [ 79-30-1 ]
  • [ 132500-92-6 ]
  • 65
  • [ 4146-43-4 ]
  • [ 2284-20-0 ]
  • [ 90748-48-4 ]
  • 66
  • [ 4146-43-4 ]
  • [ 3460-49-9 ]
  • [ 90748-49-5 ]
  • 67
  • [ 4146-43-4 ]
  • [ 23163-84-0 ]
  • [ 139004-30-1 ]
  • 68
  • [ 4146-43-4 ]
  • [ 614-69-7 ]
  • [ 139004-28-7 ]
  • 69
  • [ 4146-43-4 ]
  • [ 2243-83-6 ]
  • [ 132500-91-5 ]
  • 71
  • [ 5453-80-5 ]
  • [ 4146-43-4 ]
  • N,N'-Bis-(bicyclo<2.2.1>hepten-(5)-yl-(2)-methylen)-bernsteinsaeuredihydrazid [ No CAS ]
  • 72
  • [ 4146-43-4 ]
  • [ 19396-83-9 ]
  • N,N'-Bis-(bicyclo<2.2.1>heptyl-(2)-methylen)-bernsteinsaeuredihydrazid [ No CAS ]
  • 74
  • [ 4146-43-4 ]
  • [ 1147550-11-5 ]
  • [ 7271-35-4 ]
  • 75
  • [ 4755-81-1 ]
  • [ 4146-43-4 ]
  • 2-Chloro-3-({3-[2-chloro-2-methoxycarbonyl-1-methyl-eth-(E)-ylidene-hydrazinocarbonyl]-propionyl}-hydrazono)-butyric acid methyl ester [ No CAS ]
  • 76
  • [ 19283-13-7 ]
  • [ 7803-57-8 ]
  • [ 4146-43-4 ]
  • 77
  • [ 123-56-8 ]
  • hydrazine hydrate (2 mol) [ No CAS ]
  • alcohol (boiling) [ No CAS ]
  • [ 4146-43-4 ]
  • 78
  • [ 4146-43-4 ]
  • CS2 [ No CAS ]
  • [ 21528-04-1 ]
  • 82
  • [ 24820-65-3 ]
  • [ 7732-18-5 ]
  • [ 4146-43-4 ]
  • 83
  • barium salt of succinic acid monoethyl ester [ No CAS ]
  • [ 4146-43-4 ]
  • 84
  • ethane-tetracarboxylic acid-(1.1.2.2)-tetrahydrazide [ No CAS ]
  • [ 4146-43-4 ]
  • 85
  • N-amino-succinimide [ No CAS ]
  • [ 4146-43-4 ]
  • 86
  • [ 4146-43-4 ]
  • (1<i>R</i>)-3<i>endo</i>-isothiocyanato-bornanone-(2) [ No CAS ]
  • succinic acid bis-[<i>N</i>'-((1<i>S</i>)-3-oxo-4.7.7-trimethyl-norbornyl-(2<i>endo</i>)-thiocarbamoyl)-hydrazide] [ No CAS ]
  • 87
  • [ 75-15-0 ]
  • [ 4146-43-4 ]
  • [ 110-15-6 ]
  • [ 1072-71-5 ]
  • 88
  • [ 698-63-5 ]
  • [ 4146-43-4 ]
  • [ 94783-48-9 ]
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 4146-43-4 ]

Aliphatic Chain Hydrocarbons

Chemical Structure| 1071-93-8

[ 1071-93-8 ]

Adipohydrazide

Similarity: 0.96

Chemical Structure| 6304-39-8

[ 6304-39-8 ]

Octanehydrazide

Similarity: 0.96

Chemical Structure| 3619-17-8

[ 3619-17-8 ]

Isobutyrohydrazide

Similarity: 0.77

Chemical Structure| 541-35-5

[ 541-35-5 ]

Butyramide

Similarity: 0.74

Chemical Structure| 1068-57-1

[ 1068-57-1 ]

Acethydrazide

Similarity: 0.65

Amides

Chemical Structure| 1071-93-8

[ 1071-93-8 ]

Adipohydrazide

Similarity: 0.96

Chemical Structure| 6304-39-8

[ 6304-39-8 ]

Octanehydrazide

Similarity: 0.96

Chemical Structure| 6952-93-8

[ 6952-93-8 ]

Cyclopropanecarbohydrazide

Similarity: 0.85

Chemical Structure| 72790-89-7

[ 72790-89-7 ]

1-Methylcyclopropanecarbohydrazide

Similarity: 0.79

Chemical Structure| 3619-17-8

[ 3619-17-8 ]

Isobutyrohydrazide

Similarity: 0.77

Hydrazides

Chemical Structure| 1071-93-8

[ 1071-93-8 ]

Adipohydrazide

Similarity: 0.96

Chemical Structure| 6304-39-8

[ 6304-39-8 ]

Octanehydrazide

Similarity: 0.96

Chemical Structure| 6952-93-8

[ 6952-93-8 ]

Cyclopropanecarbohydrazide

Similarity: 0.85

Chemical Structure| 72790-89-7

[ 72790-89-7 ]

1-Methylcyclopropanecarbohydrazide

Similarity: 0.79

Chemical Structure| 3619-17-8

[ 3619-17-8 ]

Isobutyrohydrazide

Similarity: 0.77

Amines

Chemical Structure| 1071-93-8

[ 1071-93-8 ]

Adipohydrazide

Similarity: 0.96

Chemical Structure| 6304-39-8

[ 6304-39-8 ]

Octanehydrazide

Similarity: 0.96

Chemical Structure| 6952-93-8

[ 6952-93-8 ]

Cyclopropanecarbohydrazide

Similarity: 0.85

Chemical Structure| 72790-89-7

[ 72790-89-7 ]

1-Methylcyclopropanecarbohydrazide

Similarity: 0.79

Chemical Structure| 3619-17-8

[ 3619-17-8 ]

Isobutyrohydrazide

Similarity: 0.77

Hydrazines

Chemical Structure| 1071-93-8

[ 1071-93-8 ]

Adipohydrazide

Similarity: 0.96

Chemical Structure| 6304-39-8

[ 6304-39-8 ]

Octanehydrazide

Similarity: 0.96

Chemical Structure| 6952-93-8

[ 6952-93-8 ]

Cyclopropanecarbohydrazide

Similarity: 0.85

Chemical Structure| 72790-89-7

[ 72790-89-7 ]

1-Methylcyclopropanecarbohydrazide

Similarity: 0.79

Chemical Structure| 3619-17-8

[ 3619-17-8 ]

Isobutyrohydrazide

Similarity: 0.77