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Chemical Structure| 41490-13-5 Chemical Structure| 41490-13-5

Structure of 41490-13-5

Chemical Structure| 41490-13-5

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Product Details of [ 41490-13-5 ]

CAS No. :41490-13-5
Formula : C14H10Cl2O3
M.W : 297.13
SMILES Code : O=C(O)C1=CC(Cl)=C(OCC2=CC=CC=C2)C(Cl)=C1
MDL No. :MFCD06203475

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Application In Synthesis of [ 41490-13-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41490-13-5 ]

[ 41490-13-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3336-41-2 ]
  • [ 100-39-0 ]
  • [ 41490-13-5 ]
YieldReaction ConditionsOperation in experiment
74% The 4-hydroxy-3, 5-dichloro-benzoic acid (2 g, 9.6 mmol), K2CO3 (4.1 g, 20.2 mmol), and BnBr (5.4 g, 20.1 mmol) were dissolved in dry DMF and stirred for 24 h. Water was added to the reaction mixture and extracted with EtOAc thrice. The combined organic phase was evaporated and dissolved in 8N OH in MeOH (50 mL) and refluxed for another 1 h. After completion of the reaction, the mixture was acidified with concentrated HC1 to pH 2-3. The formed precipitate was filtered, dissolved in EtOAc and washed with water, brine and dried over Na2S04. Removal of the solvent gave product as light yellow color solid (2.1 g, 74percent yield). NMR (400 MHz, d6- Acetone) delta: 1 1.8 (brs, 1H), 8.01 (s, 2H), 7.59 (d, 2H), 7.42 (d, 3H), 5.1 (s, 2H); , 3C NMR (400 MHz, d6- Acetone) delta: 164.1, 136.1, 130.2, 129.6, 128.6, 128.5, 128.4, 128.2, 75.0.
 

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