Alternatived Products of [ 41598-57-6 ]
Product Details of [ 41598-57-6 ]
CAS No. : | 41598-57-6 |
MDL No. : | MFCD11557190 |
Formula : |
C11H10ClNO3
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
239.66
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 41598-57-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 41598-57-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 41598-57-6 ]
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[ 31163-12-9 ]
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[ 41598-57-6 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Inert atmosphere; Reflux
2.1: sodium hydride / tetrahydrofuran; mineral oil / 12.5 h / 20 °C / Inert atmosphere
2.2: 12 h / 20 °C / Inert atmosphere
3.1: sodium hydride / toluene; mineral oil / 4 h / 20 °C / Inert atmosphere; Reflux |
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Multi-step reaction with 3 steps
1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 4 h / Inert atmosphere; Reflux
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
2.2: 12 h / 20 °C / Inert atmosphere
3.1: sodium hydride / mineral oil / 12 h / 20 °C / Inert atmosphere |
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Multi-step reaction with 3 steps
1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 20 °C / Reflux
2.1: sodium hydride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: sodium hydride / toluene / 4 h / 10 °C / Inert atmosphere; Reflux |
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Multi-step reaction with 3 steps
1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C
2.2: 14 h / Inert atmosphere
3.1: sodium hydride / toluene / 5 h / Reflux |
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Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 10 h / Reflux; Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; toluene / 4 h / 0 °C / Reflux; Cooling with ethanol-dry ice |
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Reference:
[1]Negoro, Nobuyuki; Sasaki, Shinobu; Ito, Masahiro; Kitamura, Shuji; Tsujihata, Yoshiyuki; Ito, Ryo; Suzuki, Masami; Takeuchi, Koji; Suzuki, Nobuhiro; Miyazaki, Junichi; Santou, Takashi; Odani, Tomoyuki; Kanzaki, Naoyuki; Funami, Miyuki; Tanaka, Toshimasa; Yasuma, Tsuneo; Momose, Yu
[Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1538 - 1552]
[2]Current Patent Assignee: ABBVIE INC - WO2016/44770, 2016, A1
[3]Yang, Yaxi; Zhang, Rukang; Li, Zhaojun; Mei, Lianghe; Wan, Shili; Ding, Hong; Chen, Zhifeng; Xing, Jing; Feng, Huijin; Han, Jie; Jiang, Hualiang; Zheng, Mingyue; Luo, Cheng; Zhou, Bing
[Journal of Medicinal Chemistry, 2020, vol. 63, # 3, p. 1337 - 1360]
[4]Current Patent Assignee: SUZHOU CHIEN SHIUNG INST TECH - CN111499574, 2020, A
[5]Current Patent Assignee: Shanghai Institute of Materia Medica (in: CAS); CHINESE ACADEMY OF SCIENCES - EP3782995, 2021, A1
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[ 41598-57-6 ]