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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
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CAS No. : | 422-03-7 | MDL No. : | MFCD00042459 |
Formula : | C3H4F5N | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 149.06 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501 | UN#: | 2735 |
Hazard Statements: | H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | In toluene;Reflux; Dean-Stark; | A mixture of <strong>[58551-83-0]2,4,6-trifluorobenzaldehyde</strong> (4.5 g, 28 mmol) and 2,2,3,3,3-pentafluoropropylamine (4.2 g, 28 mmol) in toluene (30 mL) was heated at reflux overnight using a Dean-Stark apparatus. The reaction mixture was allowed to cool to room temperature and concentrated in vacuo to provide 2,2,3,3,3-pentafluoro-N-[(2,4,6-trifluorophenyl)methylene]-1-propanamine (9b, 6.6 g, 23 mmol, 81%). This material was used directly in subsequent reactions without further purification. 1H NMR (CDCl3): delta 8.50 (s, 1H), 6.80-6.72 (m, 2H), 4.23-4.16 (m, 2H). |
In toluene;Heating / reflux; Dean-Stark apparatus; | A mixture of <strong>[58551-83-0]2,4,6-trifluorobenzaldehyde</strong> (4.51 g, 28.00 mrnol) and 2,2,3,3,3- pentafluoropropylamine (4.20 g, 28.17 mmol) in toluene (30 mL) was heated at reflux overnight using Dean-Stark apparatus. The reaction mixture was allowed to cool to room temperature and concentrated in vacuo to provide 6.55g of the title product. This compound was of sufficient purity to use in subsequent reactions.1H NMR (CDCl3) 5 8.50 (s, IH)3 6.80-6.72 (m, 2H)5 4.23-4.16 (m, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | b) 2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid ethyl ester To a solution of 1.56 g (10.6 mmol) methyl-malonic acid monoethyl ester in 20 ml of tetrahydrofuran 1.58 g (10.6 mmol) of 2,2,3,3,3-pentafluoropropylamine, 2.05 g (10.6 mmol) of N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, 1.44 g (10.6 mmol) of 1-hydroxybenzotrizole hydrate and 2.75 g (21.2 mmol) of N,N-diisopropyl-ethylamine were added. The mixture was stirred at room temperature for 18 h. The mixture was poured onto 0.5 N HCl (50 ml) and afterwards extracted with dichloromethane (three times 50 ml). The combined organic layers were extracted with 0.5 N aqueous NaHCO3 solution, dried (MgSO4) and the solvent was removed by distillation. The residue was purified by column filtration (hexane/ethyl acetate=2:1) to yield 2.38 g (81%) of the title compound as white crystalline solid, MS m/e (%): 276.1 (M-H+, 100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With C33H43ClNiO6P2; sodium t-butanolate In toluene at 25℃; for 18h; Inert atmosphere; Sealed tube; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With sodium tris(acetoxy)borohydride; glacial acetic acid In tetrahydrofuran at 20℃; for 15h; | 17 Synthesis of N, N-dioctadecyl-2,2,3,3,3-pentafluoropropylamine 1-octadecanal (1.5 g, 5.59 mmol) and 2,2,3,3,3-pentafluoropropylamine (0.40 g, 2.7 mmol) and acetic acid (0.3 mL) in tetrahydrofuran (30 mL) Sodium triacetoxyborohydride (1.2 g, 5.7 mmol) was added, and the mixture was stirred at room temperature for 15 hours. A saturated aqueous sodium hydrogen carbonate solution was added to the mixture to make it basic, and the mixture was extracted with n-hexane. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane / ethyl acetate = 100 / 0-95 / 5) to give the title compound (1.65 g, 100%). |