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Chemical Structure| 422550-71-8 Chemical Structure| 422550-71-8

Structure of 422550-71-8

Chemical Structure| 422550-71-8

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Product Details of [ 422550-71-8 ]

CAS No. :422550-71-8
Formula : C11H9NO3
M.W : 203.19
SMILES Code : O=C(C1=CC=C2C(C)=CC=NC2=C1O)O

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Application In Synthesis of [ 422550-71-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 422550-71-8 ]

[ 422550-71-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3846-73-9 ]
  • [ 124-38-9 ]
  • [ 422550-71-8 ]
YieldReaction ConditionsOperation in experiment
Step 2 8-Hydroxy-4-methylquinoline-7-carboxylic acid (2b) Into a 100 mL round bottom flask fitted with a stirring bar and a nitrogen inlet was placed 50 mL dry methanol. To this was added sodium (.163 g, 6.78 mmol) and the reaction was allowed to stir until all the metal was dissolved. 4-Methylquinolin-8-ol (0.83 g, 5.21 mmol) was added and the mixture stirred for 15 min, followed by removal of the solvent in vacuo. The resulting white solid was transferred to a high pressure reaction vessel, which was charged with CO2 to 40 bar and heated to 170 C. for 3 days. After cooling and venting the gas, the brown residue was dissolved in water, filtered and acidified with 10% HCl. The water was removed in vacuo and thoroughly dried under hivac. The residue was slurried in MeOH, filtered and the solvent removed to give <strong>[3846-73-9]8-hydroxy-4-methylquinoline</strong>-7-carboxylic acid. 1H NMR (CDCl3) delta: 3.02 (3H, s); 7.73(1H, d, j=8.9 Hz), 8.05(1H, d, j=5.1 Hz); 8.27(1 H, d, j=8.9 Hz); 9.28(1H, d, j=5.3 Hz) ES MS M+1=204
 

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