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Chemical Structure| 426463-16-3 Chemical Structure| 426463-16-3

Structure of 426463-16-3

Chemical Structure| 426463-16-3

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Product Details of [ 426463-16-3 ]

CAS No. :426463-16-3
Formula : C5H2FIN2O2
M.W : 267.98
SMILES Code : O=[N+](C1=CC(I)=CN=C1F)[O-]

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Application In Synthesis of [ 426463-16-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 426463-16-3 ]

[ 426463-16-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 426463-05-0 ]
  • [ 426463-16-3 ]
YieldReaction ConditionsOperation in experiment
47% With KF; In N,N-dimethyl-formamide; 2-Fluoro-3-nitro-5-iodopyridine <strong>[426463-05-0]5-iodo-3-nitro-2-chloropyridine</strong> (0.624 g, 2.19 mmol), KF (265 mg, 58.1 mmol), and DMF (3 mL) were stirred at 120 degrees Celsius for 24 h. The mixture was poured into saturated brine, extracted with ethyl acetate, dried over sodium sulfate, then concentrated. The crude residue was purified by flash chromatography using 4-1 hexane:ethyl acetate to yield 5-iodo-3-nitro-2-fluoropyridine (279 mg, 47%) as a colorless solid. 1H NMR (CDCl3) delta (ppm) 8.70 (s, 1H), 8.77 (d, J=7.7 Hz, 1H), 13C NMR (CDCl3) delta (ppm) 86.66 (JCF32 21.5 Hz), 144.24, 152.96, 156.97, 158.27 (JCF32 58 Hz). Analytical Calculated for C5H2N2O2Fl: C, 22.41; H, 0.75; N, 10.45; Found: C, 22.57; H, 0.77; N, 10.24.
 

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