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[ CAS No. 43088-64-8 ] {[proInfo.proName]}

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Product Details of [ 43088-64-8 ]

CAS No. :43088-64-8 MDL No. :MFCD00205193
Formula : C7H6N2OS Boiling Point : -
Linear Structure Formula :- InChI Key :HRKYSEOOABTTCJ-UHFFFAOYSA-N
M.W : 166.20 Pubchem ID :290226
Synonyms :

Safety of [ 43088-64-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 43088-64-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 43088-64-8 ]
  • Downstream synthetic route of [ 43088-64-8 ]

[ 43088-64-8 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 43088-64-8 ]
  • [ 43088-67-1 ]
YieldReaction ConditionsOperation in experiment
39% at 110℃; for 1 h; Step 2. Preparation of 4-chloro-5-methyl-thienor2.3-dlpyrimidine; The compound, 5-methyl-thieno[2,3-d]pyrimidin-4-ol, (1.4g, 8.42mmol) prepared in the step 1 was dissolved in phosphorusoxy chloride (5ml). Thereafter, the reaction mixture was stirred at 11O0C for 1 hour. After reaction, the reaction mixture was poured into ice water and chloroform, and washed with water and saturated sodium hydrogen carbonate aqueous solution. Combined organic layer was concentrated under reduced pressure. The residue was purified by recrystallization (n-hexane and ethyl acetate) to give 590mg (yield: 39percent, yellow solid) of the target compound.[514] 1U NMR(400D, CDCI): δ 8.81 (s, IH), 7.24 (s, IH), 2.70 (s, 3H).
Reference: [1] Patent: WO2007/102679, 2007, A1, . Location in patent: Page/Page column 49
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 6, p. 1525 - 1528
  • 2
  • [ 43088-64-8 ]
  • [ 43088-67-1 ]
Reference: [1] Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968, vol. 266, p. 1706 - 1708
[2] Tetrahedron Letters, 2010, vol. 51, # 25, p. 3269 - 3273
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