Alternatived Products of [ 4310-42-3 ]
Product Details of [ 4310-42-3 ]
CAS No. : | 4310-42-3 |
MDL No. : | MFCD02665276 |
Formula : |
C10H8N2O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
188.18
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 4310-42-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 4310-42-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 4310-42-3 ]
- 1
-
[ 4310-42-3 ]
-
[ 89353-42-4 ]
Yield | Reaction Conditions | Operation in experiment |
82.1% |
With palladium on activated charcoal; hydrazine hydrate In ethanol at 20℃; for 0.5h; |
13.2 2. Synthesis of intermediate d3
Dissolve the intermediate c3 (7.3g, 0.039mol) in EtOH (50mL),Add Pd / C (0.73g, 6.93mmol), N2H4H2O (19.5g, 0.039mol), react at room temperature for 0.5h, suction filter, and pour the filtrate into 200mL of water.Extracted with dichloromethane (50mL × 3), separated the organic phase and dried over anhydrous sodium sulfate.After filtration, the filtrate was concentrated, and the product was separated by silica gel column chromatography to obtain 5.04 g of the product, with a yield of 82.1%. |
47.6% |
With hydrogen |
|
- 2
-
[ 109-97-7 ]
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[ 645-00-1 ]
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[ 4310-42-3 ]
-
[ 89353-42-4 ]
Yield | Reaction Conditions | Operation in experiment |
1: 69 %Chromat.
2: 25 %Chromat. |
With caesium carbonate at 135℃; for 15h; |
General procedure: A mixture of pyrrole (3 ml), Cs2CO3 (1.96 g, 6 mmol), Cu0/4A or Cu2+/4A (0.3 g) and the appropriate aryl halide (3 mmol) were stirred at 135 °C (bath temperature) for 4-36 h. Before adding to the mixture, Cu2+/4A was preheated at ca. 150 °C for 1 h. The mixture was filtered, the solid was washed with dichloromethane. The filtrate was extracted with deionised water (2 x 40 ml). The organic phase was dried over Na2SO4 and concentrated in vacuum. The residue was distilled and clarified. Certain products (3c, 3f) were purified by recrystallization from MeOH. |
1: 81 %Chromat.
2: 10 %Chromat. |
With caesium carbonate at 115℃; for 4h; |
General procedure: A mixture of pyrrole (3 ml), Cs2CO3 (1.96 g, 6 mmol), Cu0/4A or Cu2+/4A (0.3 g) and the appropriate aryl halide (3 mmol) were stirred at 135 °C (bath temperature) for 4-36 h. Before adding to the mixture, Cu2+/4A was preheated at ca. 150 °C for 1 h. The mixture was filtered, the solid was washed with dichloromethane. The filtrate was extracted with deionised water (2 x 40 ml). The organic phase was dried over Na2SO4 and concentrated in vacuum. The residue was distilled and clarified. Certain products (3c, 3f) were purified by recrystallization from MeOH. |
Reference:
[1]Nmeth, Jnos; Debreczeni, Nra; Gresits, Ivn; Blint, Mria; Hell, Zoltn
[Catalysis Letters, 2015, vol. 145, # 5, p. 1113 - 1119]
[2]Nmeth, Jnos; Debreczeni, Nra; Gresits, Ivn; Blint, Mria; Hell, Zoltn
[Catalysis Letters, 2015, vol. 145, # 5, p. 1113 - 1119]