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[ CAS No. 4310-42-3 ] {[proInfo.proName]}

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Chemical Structure| 4310-42-3
Chemical Structure| 4310-42-3
Structure of 4310-42-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 4310-42-3 ]

CAS No. :4310-42-3 MDL No. :MFCD02665276
Formula : C10H8N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 188.18 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 4310-42-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4310-42-3 ]

[ 4310-42-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4310-42-3 ]
  • [ 89353-42-4 ]
YieldReaction ConditionsOperation in experiment
82.1% With palladium on activated charcoal; hydrazine hydrate In ethanol at 20℃; for 0.5h; 13.2 2. Synthesis of intermediate d3 Dissolve the intermediate c3 (7.3g, 0.039mol) in EtOH (50mL),Add Pd / C (0.73g, 6.93mmol), N2H4H2O (19.5g, 0.039mol), react at room temperature for 0.5h, suction filter, and pour the filtrate into 200mL of water.Extracted with dichloromethane (50mL × 3), separated the organic phase and dried over anhydrous sodium sulfate.After filtration, the filtrate was concentrated, and the product was separated by silica gel column chromatography to obtain 5.04 g of the product, with a yield of 82.1%.
47.6% With hydrogen
  • 2
  • [ 109-97-7 ]
  • [ 645-00-1 ]
  • [ 4310-42-3 ]
  • [ 89353-42-4 ]
YieldReaction ConditionsOperation in experiment
1: 69 %Chromat. 2: 25 %Chromat. With caesium carbonate at 135℃; for 15h; General procedure: A mixture of pyrrole (3 ml), Cs2CO3 (1.96 g, 6 mmol), Cu0/4A or Cu2+/4A (0.3 g) and the appropriate aryl halide (3 mmol) were stirred at 135 °C (bath temperature) for 4-36 h. Before adding to the mixture, Cu2+/4A was preheated at ca. 150 °C for 1 h. The mixture was filtered, the solid was washed with dichloromethane. The filtrate was extracted with deionised water (2 x 40 ml). The organic phase was dried over Na2SO4 and concentrated in vacuum. The residue was distilled and clarified. Certain products (3c, 3f) were purified by recrystallization from MeOH.
1: 81 %Chromat. 2: 10 %Chromat. With caesium carbonate at 115℃; for 4h; General procedure: A mixture of pyrrole (3 ml), Cs2CO3 (1.96 g, 6 mmol), Cu0/4A or Cu2+/4A (0.3 g) and the appropriate aryl halide (3 mmol) were stirred at 135 °C (bath temperature) for 4-36 h. Before adding to the mixture, Cu2+/4A was preheated at ca. 150 °C for 1 h. The mixture was filtered, the solid was washed with dichloromethane. The filtrate was extracted with deionised water (2 x 40 ml). The organic phase was dried over Na2SO4 and concentrated in vacuum. The residue was distilled and clarified. Certain products (3c, 3f) were purified by recrystallization from MeOH.
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