Alternatived Products of [ 4313-56-8 ]
Product Details of [ 4313-56-8 ]
CAS No. : | 4313-56-8 |
MDL No. : | MFCD12198034 |
Formula : |
C7H15NO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
129.20
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 4313-56-8 ]
Signal Word: | Warning |
Class: | N/A |
Precautionary Statements: | P305+P351+P338 |
UN#: | N/A |
Hazard Statements: | H319 |
Packing Group: | N/A |
GHS Pictogram: |
|
Application In Synthesis of [ 4313-56-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 4313-56-8 ]
- 1
-
[ 4313-56-8 ]
-
[ 207557-35-5 ]
-
(S)-1-[2-(1-Hydroxymethyl-cyclohexylamino)-acetyl]-pyrrolidine-2-carbonitrile
[ No CAS ]
- 2
-
[ 4313-56-8 ]
-
[ 188593-96-6 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 97 percent / MgSO4 / diethyl ether / 18 h / Ambient temperature
2: 94 percent / NaBH4 / methanol / 18 h / Ambient temperature |
|
- 3
-
[ 4313-56-8 ]
-
[ 13544-44-0 ]
-
(1-((2-chloro-5-iodopyrimidin-4-yl)amino)cyclohexyl)methanol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
1.5 g |
With sodium hydrogencarbonate; In N,N-dimethyl acetamide; at 80℃; for 4h; |
To a solution of <strong>[13544-44-0]2,4-dichloro-5-iodopyrimidine</strong> (247, 2.7 g, 9.8 mmol) in DMA (20 mL) was added (1-aminocyclohexyl)methanol (244, 1.4 g, 10.8 mmol) and NaHCO3 (5 g, 59.5 mol).The reaction was stirred at 80 C for 4 h. After cooling to room temperature, the reaction mixture was quenched with water (40 mL) and extracted with EtOAc (50 mL x 2). Thecombined organic phases were concentrated in vacuo to afford the residue, which was purified by column chromatography to afford (1-((2-chloro-5-iodopyrimidin-4- yl)amino)cyclohexyl)methanol (248, 1.5 g, 4.1 mmol). MS (ESI): m/z 368 [M + Hj |
- 4
-
[ 381-88-4 ]
-
[ 4313-56-8 ]
-
2-ethyl-2-(trifluoromethyl)-3-oxa-1-azaspiro[4.5]decane
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
53% |
With toluene-4-sulfonic acid at 120℃; for 16h; Sealed tube; Molecular sieve; |
|
- 5
-
[ 2955-62-6 ]
-
[ 4313-56-8 ]
-
methyl 3-(2-ethyl-3-oxa-1-azaspiro[4.5]decan-2-yl)propanoate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
38% |
With toluene-4-sulfonic acid In toluene for 16h; Dean-Stark; Reflux; |
|
- 6
-
[ 4313-56-8 ]
-
[ 265664-91-3 ]
-
2-((benzyloxy)methyl)-2-ethyl-3-oxa-1-azaspiro[4.5]decane
[ No CAS ]
- 7
-
[ 1123-86-0 ]
-
[ 4313-56-8 ]
-
2-cyclohexyl-2-ethyl-3-oxa-1-azaspiro[4.5]decane
[ No CAS ]
- 8
-
[ 14371-10-9 ]
-
[ 2039-93-2 ]
-
[ 4313-56-8 ]
-
3-ethyl-2,3-diphenylcyclobutane-1-carbaldehyde
[ No CAS ]
-
3-ethyl-2,3-diphenylcyclobutane-1-carbaldehyde
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
93 % ee |
Stage #1: (E)-3-phenylpropenal; (1-aminocyclohexyl)methanol In dichloromethane at 20℃; for 24h; Molecular sieve; Inert atmosphere; Schlenk technique;
Stage #2: 1-ethylstyrene With 2,2'-{((11bR)-4-hydroxy-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine-2,6-diyl)bis(3,1-phenylene)}bis(9H-thioxanthen-9-one) In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran at -50℃; for 15h; Inert atmosphere; Schlenk technique; Irradiation; Overall yield = 11.9 mg; stereoselective reaction; |
|
Reference:
[1]Bach, Thorsten; Gramüller, Johannes; Gschwind, Ruth M.; Hörmann, Fabian M.; Pecho, Franziska; Sempere, Yeshua
[Journal of the American Chemical Society, 2021, vol. 143, # 25, p. 9350 - 9354]