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Chemical Structure| 43153-04-4 Chemical Structure| 43153-04-4

Structure of 43153-04-4

Chemical Structure| 43153-04-4

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Product Details of [ 43153-04-4 ]

CAS No. :43153-04-4
Formula : C12H14O3
M.W : 206.24
SMILES Code : O=CC1=CC=C(C=C1)C(C(OCC)=O)C

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Application In Synthesis of [ 43153-04-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 43153-04-4 ]

[ 43153-04-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 126-33-0 ]
  • [ 43153-04-4 ]
  • [ 1012312-23-0 ]
YieldReaction ConditionsOperation in experiment
39% Example 38 Ethyl 2-{4-[(1,1-dioxotetrahydro-1lambda6-thiophen-2-yl)hydroxymethyl]phenyl}propionate Tetrahydrothiophene-1,1-dioxide (1.5 g) was dissolved in tetrahydrofuran (10 ml), and to the solution was added dropwise a 1.6 M solution of n-butyllithium in hexane (6.0 ml) at -60C. The reaction mixture was gradually warmed to 0C, stirred at the same temperature for 30 minutes, then a solution of ethyl 2-(4-formylphenyl)propionate (1.5 g) in tetrahydrofuran (2.0 ml) was added dropwise at 0C, and the mixture was stirred at room temperature for 2 days. The reaction mixture was quenched with 10% aqueous citric acid, and then extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over sodium sulfate. The solvent was evaporated under reduced pressure, and then the residue was purified by silica gel column chromatography (hexane/ethyl acetate = 2/1) to give the title compound (800 mg, 39%). 1H-NMR (CDCl3) delta; 1.21 (3H, t, J=7.3Hz), 1.49 (3H, d, J=7.3Hz), 1.90-2.10 (2H, m), 2.16-2.41 (2H, m), 2.94-3.08 (1H, m), 3.12-3.26 (2H, m), 3.31 (1H, d, J=3.0Hz), 3.70 (1H, q, J=7.3Hz), 4.02-4.22 (2H, m), 5.44-5.50 (1H, m), 7.27-7.36 (4H, m).
 

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