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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 4402-24-8 Chemical Structure| 4402-24-8

Structure of 4402-24-8

Chemical Structure| 4402-24-8

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4.5 *For Research Use Only !

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Product Citations

Product Citations

Gupta, Pradeep Kumar ; Orlovskiy, Stepan ; Arias-Mendoza, Fernando ; Nelson, David S. ; Osborne, Aria ; Pickup, Stephen , et al.

Abstract: therapy for metastatic melanoma focuses on blocking growth-promoting signals produced by a hyperactive BRAF protein. We report the metabolic differences of four human melanoma cell lines with diverse responses to therapy (30 mg/kg; oral): WM3918 < WM9838BR < WM983B < DB-1. Our goal was to determine if metabolic changes produced by the altered signaling pathway due to BRAF mutations differ in the melanoma models and whether these differences correlate with response to treatment. We assessed metabolic changes in isolated cells using high-resolution proton magnetic resonance spectroscopy (1H MRS) and supplementary biochemical assays. We also noninvasively studied mouse xenografts using proton and phosphorus (1H/31P) MRS. We found consistent changes in lactate and , either in isolated cells or mouse xenografts, correlating with their relative responsiveness. In xenografts, we also observed that a more significant response to correlated with higher bioenergetics (i.e., increased βNTP/Pi). Notably, our noninvasive assessment of the metabolic status of the human melanoma xenografts by 1H/31P MRS demonstrated early metabolite changes preceding therapy response (i.e., tumor shrinkage). Therefore, this noninvasive methodology could be translated to assess in vivo predictive metabolic biomarkers of response in melanoma patients under and probably other signaling inhibition therapies.

Keywords: BRAF ; cancer biomarkers ; ; magnetic resonance spectroscopy ; melanoma ; response prediction

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Product Details of [ 4402-24-8 ]

CAS No. :4402-24-8
Formula : C7H18NO3P
M.W : 195.20
SMILES Code : NCCCP(OCC)(OCC)=O
MDL No. :MFCD11110596
InChI Key :DQORFBNFNLHVIM-UHFFFAOYSA-N
Pubchem ID :78113

Safety of [ 4402-24-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P260-P264-P280-P305+P351+P338-P405-P501
Class:8
UN#:2735
Packing Group:
 

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