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Chemical Structure| 441-29-2 Chemical Structure| 441-29-2

Structure of 441-29-2

Chemical Structure| 441-29-2

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Product Details of [ 441-29-2 ]

CAS No. :441-29-2
Formula : C11H8F3NO
M.W : 227.18
SMILES Code : CC(N1)=C(C(C(F)(F)F)=O)C2=C1C=CC=C2

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Application In Synthesis of [ 441-29-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 441-29-2 ]

[ 441-29-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 441-29-2 ]
  • [ 63176-44-3 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; at 55℃; General procedure: One of compounds 3a-3f (20 mmol) was dissolved in DMF (10 mL). Trifluoroacetic anhydride (4.2 mL, 30 mmol) was added dropwise at 0C. After stirring for 3.5 h, water was added, the solid filtered off and treated with 20% NaOH (40 mL, 0.2 mol) at 55C overnight. Upon cooling down, the solution was extracted with Et2O. The aqueous phase was acidified with concentrated HCl and the residue was filtered off to give one of compounds 4a-4f.
 

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