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Chemical Structure| 441304-52-5 Chemical Structure| 441304-52-5

Structure of 441304-52-5

Chemical Structure| 441304-52-5

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Product Details of [ 441304-52-5 ]

CAS No. :441304-52-5
Formula : C10H9IO5
M.W : 336.08
SMILES Code : O=C(C1=C(I)C(OC)=C(OCO2)C2=C1)OC

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Application In Synthesis of [ 441304-52-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 441304-52-5 ]

[ 441304-52-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 568577-88-8 ]
  • [ 441304-52-5 ]
  • C20H21NO6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; In tetrahydrofuran; water; at 70℃; for 4h; Example 4 [0060] [0061] Iodo Compound 3 (0.1 mmol) obtained in Example 1 and 4-morpholinyl phenylboronic acid pinacol ester (CAS: 568577-88-8) (0.5 mmol) were put in a 25 mL round-bottomed flask, followed by addition of Pd(OAc)2 (0.05 mmol), Bu4NBr (0.15 mmol), K2CO3 (0.3 mmol), and 3 mL THF-H2O (VTHF/VH2O=1). The mixture was heated to 70 C. and the reaction was carried out for 4 hours. The reaction solution was cooled to room temperature, filtered, concentrated, and purified by silica gel column to give Compound 7. [0062] The relevant test data were as follows: 1H-NMR (300 MHz, CDCl3): delta=6.92 (s, 1H), 6.03 (s, 2H), 3.85-3.89 (t, 4H), 3.76 (s, 3H), 3.56 (s, 3H), 3.19-3.22 (t, 4H); 13C-NMR (75 MHz, CDCl3): delta=168.39, 150.00, 147.92, 141.67, 140.78, 128.01, 104.52, 101.83, 66.98, 60.05, 51.95, 49.06.
 

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