Home Cart Sign in  
Chemical Structure| 442847-52-1 Chemical Structure| 442847-52-1

Structure of 442847-52-1

Chemical Structure| 442847-52-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 442847-52-1 ]

CAS No. :442847-52-1
Formula : C12H17Cl2N3OSi
M.W : 318.27
SMILES Code : C[Si](CCOCN1C=CC2=C(Cl)N=C(Cl)N=C21)(C)C
MDL No. :MFCD08689864

Safety of [ 442847-52-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Application In Synthesis of [ 442847-52-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 442847-52-1 ]

[ 442847-52-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 442847-52-1 ]
  • [ 1197953-47-1 ]
  • (2-((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
33.8% With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20℃; for 5.0h; At 0 deg. C, Example 1K (300 mg, 1.77 mmol) in DMF (5.0mL) solution was added NaH (106 mg, 2.66 mmol). Then add portionwise 2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (677 mg, 2.13 mmol) to the reaction mixture. The reaction mixture was stirred at 20 deg.C for 5 hours. TLC (methanol: DCM = 20: 1) showed the reaction was complete. The mixture was diluted with EtOAc (20mL), and washed with water (10mL). The organic layer was dried and concentrated. The crude product was purified by preparative TLC (DCM: methanol = 10: 1) to give the title compound (270 mg of, yield 33.8percent) as a yellow oil.
 

Historical Records