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[ CAS No. 443955-90-6 ] {[proInfo.proName]}

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Chemical Structure| 443955-90-6
Chemical Structure| 443955-90-6
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Product Details of [ 443955-90-6 ]

CAS No. :443955-90-6 MDL No. :MFCD09907902
Formula : C8H7NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :OMWBUWDHEZIMGQ-UHFFFAOYSA-N
M.W : 165.15 Pubchem ID :21873668
Synonyms :

Safety of [ 443955-90-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 443955-90-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 443955-90-6 ]
  • Downstream synthetic route of [ 443955-90-6 ]

[ 443955-90-6 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 443955-89-3 ]
  • [ 443955-90-6 ]
YieldReaction ConditionsOperation in experiment
61% With manganese(IV) oxide In dichloromethane for 72 h; c) 2,3-Dihydro-[1 ,4]dioxino[2,3-c]pyridine-7-carboxaldehyde; A solution of (2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61 percent); MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of (2,3-Dihydro-[1 ,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61 percent); MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of (2,3-dihydro-[1 ,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 ml_) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61 percent); MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of 2,3-dihydro[1 ,4]dioxino[2,3-c]pyridin-7-ylmethanol (250 mg, 1.5 mmole) in CH2CI2 (5 ml.) was treated with MnO2 (650 mg, 7.5 mmole). After 3 days the mixture was filtered and the filtrate was concentrated to afford the title compound (150 mg, 61 percent) as a white solid: MS (APCI+) m/e 166 (M + H)+.
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of (6b) (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61percent). MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of (b) (250 mg, 1.5 mmol) in dichloromethane (5 ml) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, [61 percent).] MS (APCI+) [M/Z] 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; c) 2,3-Dihydro-[1 ,4]dioxino[2,3-c]pyridine-7-carboxaldehyde; A solution of (2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61percent); MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; (c) 2,3-Dihydro-[1,4]dioxino[2,3-c]pyridine-7-carboxaldehyde; A solution of (2,3Ldihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61percent); MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of (2,3-Dihydro-[1 ,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61 percent); MS (APCI+) m/z 166 (MH+).
61% With manganese(IV) oxide In dichloromethane for 72 h; A solution of (2,3-Dihydro-[1 ,4]dioxino[2,3-c]pyridin-7-yl)-methanol (250 mg, 1.5 mmol) in dichloromethane (5 mL) was treated with manganese dioxide (650 mg, 7.5 mmol). After 3 days the mixture was filtered and evaporated affording a white solid (150 mg, 61 percent): LC/MS (APCI+) m/z 166 (M+H+)
0.4 g With Dess-Martin periodane In dichloromethane at 20℃; for 1 h; To a stirred solution of dess martin periodinane (1.3 g, 2.96mmol) in CH2C12 (8ml), was added dropwise, a solution of compound 9d (0.45 g, 2.7mmol) in CH2C12 (8ml). The reaction was stirred for 1 h at RT. The reaction was quenched with 1.3M NaOH solution (5ml), then with water and extracted with diethyl ether. The ether layers were dried over sodium sulphate and concentrated under reduced pressure to afford the required compound as a mixture (0.4g). Proceeded to the next step with crude.

Reference: [1] Patent: WO2006/81264, 2006, A1, . Location in patent: Page/Page column 26-27
[2] Patent: WO2006/81289, 2006, A2, . Location in patent: Page/Page column 24
[3] Patent: WO2006/81182, 2006, A2, . Location in patent: Page/Page column 25
[4] Patent: WO2007/118130, 2007, A2, . Location in patent: Page/Page column 33
[5] Patent: WO2004/2490, 2004, A2, . Location in patent: Page/Page column 54-55
[6] Patent: WO2004/2992, 2004, A1, . Location in patent: Page 89
[7] Patent: WO2006/2047, 2006, A2, . Location in patent: Page/Page column 94-95
[8] Patent: WO2006/17326, 2006, A1, . Location in patent: Page/Page column 26
[9] Patent: WO2006/20561, 2006, A2, . Location in patent: Page/Page column 36
[10] Patent: WO2007/16610, 2007, A2, . Location in patent: Page/Page column 37
[11] Tetrahedron Letters, 2010, vol. 51, # 38, p. 5038 - 5040
[12] Patent: WO2003/87098, 2003, A1, . Location in patent: Page/Page column 61
[13] Patent: EP2221309, 2010, A1, . Location in patent: Page/Page column 19
[14] Patent: WO2006/21448, 2006, A1, . Location in patent: Page/Page column 70-71
[15] Patent: US2010/324030, 2010, A1, . Location in patent: Page/Page column 13
[16] Patent: WO2014/57415, 2014, A2, . Location in patent: Page/Page column 17
  • 2
  • [ 501-30-4 ]
  • [ 443955-90-6 ]
Reference: [1] Patent: WO2014/57415, 2014, A2,
  • 3
  • [ 15771-06-9 ]
  • [ 443955-90-6 ]
Reference: [1] Patent: WO2014/57415, 2014, A2,
  • 4
  • [ 59281-14-0 ]
  • [ 443955-90-6 ]
Reference: [1] Patent: WO2014/57415, 2014, A2,
  • 5
  • [ 31883-16-6 ]
  • [ 443955-90-6 ]
Reference: [1] Patent: WO2014/57415, 2014, A2,
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