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Chemical Structure| 444915-54-2 Chemical Structure| 444915-54-2

Structure of 444915-54-2

Chemical Structure| 444915-54-2

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Product Details of [ 444915-54-2 ]

CAS No. :444915-54-2
Formula : C8H5ClF4
M.W : 212.57
SMILES Code : FC(C1=CC=C(C=C1F)CCl)(F)F
MDL No. :MFCD13185659
InChI Key :LBRMEGUZSFQNIT-UHFFFAOYSA-N
Pubchem ID :22262070

Safety of [ 444915-54-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H318
Precautionary Statements:P280-P301+P312+P330-P305+P351+P338+P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 444915-54-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 444915-54-2 ]

[ 444915-54-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 230295-16-6 ]
  • [ 444915-54-2 ]
YieldReaction ConditionsOperation in experiment
87% With thionyl chloride; In chloroform; for 4h;Heating / reflux; To a solution of <strong>[230295-16-6]3-fluoro-4-(trifluoromethyl)benzyl alcohol</strong> (10 g, 52 mmol) in chloroform (20 ml) was added thionyl chloride (18.5 ml, 257 mmol) and the mixture was heated under reflux for 4 hrs. The reaction solution was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to give 3-fluoro-4-(trifluoromethyl)benzyl chloride (9.52 g, 87%). IR nu maxKBrcm-1: 1634, 1589, 1512, 1435.1H-NMR (CDCl3) delta: 4.58 (2H, s), 7.20-7.32 (2H, m), 7.60 (1H, t, J = 7.6 Hz).
 

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