Home Cart Sign in  
Chemical Structure| 453565-48-5 Chemical Structure| 453565-48-5

Structure of 453565-48-5

Chemical Structure| 453565-48-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 453565-48-5 ]

CAS No. :453565-48-5
Formula : C7H6N4O
M.W : 162.15
SMILES Code : N/C(C1=NC=C(C#N)C=C1)=N\O
MDL No. :MFCD22628344

Safety of [ 453565-48-5 ]

Application In Synthesis of [ 453565-48-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 453565-48-5 ]

[ 453565-48-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 79-37-8 ]
  • [ 406719-77-5 ]
  • [ 453565-48-5 ]
  • [ 453567-48-1 ]
YieldReaction ConditionsOperation in experiment
16% With triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; (c) 3-(5-Fluoropyrid-2-yl)-5-(4-cyano-2-thienyl)-1,2,4-oxadiazole To a mixture of <strong>[406719-77-5]4-cyano-2-thiophenecarboxylic acid</strong> (70 mg, 0.46 mmol), oxalyl chloride (1 mIs, 2M solution in CH2Cl2, 2 mmol) in CH2Cl2 (5 ml) was added a few drops of DMF (one pipette drops) and the mixture was stirred at room temperature for 3 h. The solvent was then removed in vacuo. The residue was then dissolved in CH2Cl2 (5 ml) followed by the addition of 5-cyano-2-pyridyl amidoxime (71 mg, 0.46 mmol) and Et3N (0.2 ml) and stirring was continued for a further 1 h. Removal of the solvent in vacuo gave the crude residue which was dissolved in DMF (2 ml). The resulting solution was heated to 120 C. overnight after which the solvent was removed in vacuo and the residue was trituated with 20% ethylacetate/hexane giving the product as an off-white solid (20 mg, 16% yield). 1H-NMR(CDCl3): 8.68 (d, 1H), 8.25 (d,1H), 8.22 (s,1H), 8.17 (s, 1H), 7.61 (s, 1H).
 

Historical Records