Alternatived Products of [ 454-63-7 ]
Product Details of [ 454-63-7 ]
CAS No. : | 454-63-7 |
MDL No. : | MFCD00102143 |
Formula : |
C7H11F3O
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
168.16
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 454-63-7 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 454-63-7 ]
- Downstream synthetic route of [ 454-63-7 ]
- 1
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[ 454-63-7 ]
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[ 585-36-4 ]
Yield | Reaction Conditions | Operation in experiment |
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With Dess-Martin periodane; In dichloromethane; at 20℃; for 4h; |
To a solution of this cyclohexanol intermediate (3.0 g, 17.85 mmol) in dichloromethane (100 mL) was added Dess-Martin reagent (9.0 g, 21.42 mmol). After stirring at room temperature for 4 h, the mixture was quenched with saturated sodium bicarbonate solution. The resulting mixture was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give the ketone as a colorless oil. |
- 2
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[ 454-63-7 ]
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[ 585-36-4 ]
- 3
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[ 454-63-7 ]
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[ 64-19-7 ]
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chromium trioxide
[ No CAS ]
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[ 585-36-4 ]
- 4
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[ 401-75-2 ]
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[ 454-63-7 ]
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[ 75091-92-8 ]
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[ 585-36-4 ]
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[ 75091-99-5 ]
- 5
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[ 98-17-9 ]
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[ 454-63-7 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: 54 percent / H2 / Pt black / 8 h / 20 - 25 °C / 36.8 Torr
2: 70 percent / 10percent aq. NaOH / ethanol / 1 h / 60 - 70 °C |
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With hydrogen In methanol for 16h; |
24; 36
To a solution of 3-(trifluromethyl)-phenol (3.0 g, 18.51 mmol) in methanol (20 mL) was added Rh/Al2O3 (100 mg). The resulting mixture was stirred under hydrogen atmosphere (50 psi) for 16 h. The reaction was filtered through celite and concentrated to give the cyclohexanol as a colorless oil. |
47 μmol |
With oxalic acid In water at 19.84℃; for 1h; Inert atmosphere; UV-irradiation; |
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Reference:
[1]Zalesskaya, I. M.; Blakitnyi, A. N.; Saenko, E. P.; Fialkov, Yu. A.; Yagupol'skii, L. M.
[Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1031 - 1038][Zhurnal Organicheskoi Khimii, 1980, vol. 16, # 6, p. 1194 - 1202]
[2]Current Patent Assignee: MERCK & CO INC - US2006/293364, 2006, A1
Location in patent: Page/Page column 31; 51
[3]Kinoshita, Atsufumi; Nakanishi, Kousuke; Yagi, Ryosuke; Tanaka, Atsuhiro; Hashimoto, Keiji; Kominami, Hiroshi
[Applied Catalysis A: General, 2019, vol. 578, p. 83 - 88]
- 6
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[ 585-36-4 ]
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[ 454-63-7 ]