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Chemical Structure| 455957-87-6 Chemical Structure| 455957-87-6

Structure of 455957-87-6

Chemical Structure| 455957-87-6

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Product Details of [ 455957-87-6 ]

CAS No. :455957-87-6
Formula : C9H9BrClNO2
M.W : 278.53
SMILES Code : O=C(N(OC)C)C1=CC(Cl)=CC=C1Br
MDL No. :MFCD11847251

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Application In Synthesis of [ 455957-87-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 455957-87-6 ]

[ 455957-87-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 455957-87-6 ]
  • [ 75-16-1 ]
  • [ 935-99-9 ]
YieldReaction ConditionsOperation in experiment
Methylmagnesium bromide (4.26 mL of a 1.4M solution in tetrahydrofuran/toluene, 5.97 mmol) was added dropwise to a stirred solution of 2-bromo-5-chloro-N-methoxy-N-methylbenzamide (3-1) (0.554 g, 1.99 mmol) in tetrahydrofuran (20 mL) at approximately 0° C. After 1 h, 1N hydrochloric acid (5 mL) was added and the resulting biphasic mixture was stirred vigorously for about 10 min. The reaction mixture was poured into water and extracted three times with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated in vacuo. Purification of the crude residue by flash chromatography on silica gel (gradient elution; 0-10percent ethyl acetate/hexanes as eluent) provided 3-3 (0.44 g) as a colorless oil.
 

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