Home Cart Sign in  
Chemical Structure| 460096-34-8 Chemical Structure| 460096-34-8

Structure of 460096-34-8

Chemical Structure| 460096-34-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 460096-34-8 ]

CAS No. :460096-34-8
Formula : C14H15NO3
M.W : 245.27
SMILES Code : O=C(N1C=CC2=C1C=CC=C2C=O)OC(C)(C)C
MDL No. :MFCD11054090

Safety of [ 460096-34-8 ]

Application In Synthesis of [ 460096-34-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 460096-34-8 ]

[ 460096-34-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 676448-17-2 ]
  • [ 68-12-2 ]
  • [ 460096-34-8 ]
YieldReaction ConditionsOperation in experiment
75% t-BuLi (1.5 M in pentane, 3.37 mL, 5.06 mmol) was added to a stirred solution of compound 4 (1 g, 3.37 mmol) in THF (20 mL) at -78 C. The reaction mixture was stirred for 5 min under nitrogen and then anhydrous DMF (0.78 mL, 10.1 mmol) was added. The reaction mixture was stirred at the same temperature for another 5 min. Saturated NH4Cl solution (10 mL) was added and the reaction mixture was allowed to warm to room temperature. It was diluted with water (20 mL) and extracted with ethyl acetate (3 x 40 mL). The organic layer was washed with water, aqueous sodium chloride solution, dried over anhydrous Na2SO4 and concentrated. The crude compound was purified by silica gel column chromatography using 0-5% ethyl acetate in pet-ether to afford compound 5 (0.62 g, 75% yield) as a pale brown viscous liquid. IR (KBr): 2980, 2724, 1738, 1694, 1436, 1338, 1126, 763, 850 cm-1. 1H NMR (CDCl3, 400 MHz): delta 1.68 (S, 9H), 7.4 (d, 1H, J=3.6 Hz), 7.47 (t, 1H, J=7.6 Hz), 7.73 (d, 1H, J=7.6 Hz), 7.77 (d, 1H, J=3.6 Hz), 8.47 (d, 1H, J=8 Hz), 10.24 (S, 1H). 13C NMR (CDCl3, 100 MHz): delta 28.12, 84.42, 106.64, 116.05, 116.39, 120.99, 123.81, 128.4, 128.8, 135.94, 149.33, 192.53. MS (ESI+) m/z 246.13 [M+H]+, 146.03 [M+H-Boc]+
 

Historical Records

Technical Information

Categories