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Chemical Structure| 472964-40-2 Chemical Structure| 472964-40-2

Structure of 472964-40-2

Chemical Structure| 472964-40-2

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Product Details of [ 472964-40-2 ]

CAS No. :472964-40-2
Formula : C14H13ClF3N
M.W : 287.71
SMILES Code : NCC1=CC(C2=CC=C(C(F)(F)F)C=C2)=CC=C1.[H]Cl

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Application In Synthesis of [ 472964-40-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 472964-40-2 ]

[ 472964-40-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 472964-40-2 ]
  • [ 51293-47-1 ]
  • (S)-2-tert-butoxycarbonylamino-3-methoxypropionic acid 4'-trifluoromethylbiphenyl-3-ylmethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
260 mg With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25℃; for 14h; Example 52 (S)-2-[(4-Fluoro-benzenesulfonyl)-methyl-amino]-3-methoxy-N-(4'-trifluoromethyl-biphenyl-3- ylmethyl)-propionamide A solution of (4'-trifluoromethyl-biphenyl-3-yl)-methylamine from Example 1 (229 mg, 912 muiotaetaomicron) and (S)-2-teri-butoxycarbonylamino-3-methoxy-propionic acid (200 mg, 912 muiotaetaomicron) and N,N- diisopropylethylamine (478 muEpsilon, 2.74 mmol) in DMF (6 mL) at 25°C was treated with HATU (694 mg, 1.82 mmol). The reaction mixture was stirred for 14 h. The reaction mixture was then poured into saturated, aqueous NH4C1 and extracted three times with ethyl acetate. The combined organic layers were washed twice with water and once with brine. The organic layer was then dried over magnesium sulfate, filtered and concentrated in vacuo. Flash chromatography (50/50 hexanes/ethyl acetate) afforded (S)-2-teri-butoxycarbonylamino-3-methoxy-propionic acid 4'-trifluoromethyl- biphenyl-3-ylmethyl ester (260 mg) as a heavy oil. MH+ = 453.0
 

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