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Chemical Structure| 473918-48-8 Chemical Structure| 473918-48-8

Structure of 473918-48-8

Chemical Structure| 473918-48-8

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Product Details of [ 473918-48-8 ]

CAS No. :473918-48-8
Formula : C14H12N2
M.W : 208.26
SMILES Code : NC1=CC=CC=C1N2C=CC3=C2C=CC=C3
MDL No. :MFCD11106842

Safety of [ 473918-48-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 473918-48-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 473918-48-8 ]

[ 473918-48-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 26767-16-8 ]
  • [ 473918-48-8 ]
  • 6-(2-bromophenyl)indolo[1,2-a]quinoxaline [ No CAS ]
YieldReaction ConditionsOperation in experiment
63% With ammonium persulfate; palladium diacetate; In diethylene glycol dimethyl ether; at 78℃; for 12h; 0.2 mmol of 2-(1H-indol-1-yl)aniline, 0.01 mmol of palladium acetate, 0.4 mmol of ammonium persulfate and 0.4 mmol of <strong>[26767-16-8]2-bromobenzoylformic acid</strong> were successively added to the reaction tube. Then add 2 ml of diethylene glycol dimethyl ether as solvent.The reaction was stopped after stirring the reaction at 78 C for 12 hours.Cool to room temperature and filter,The filtrate was extracted 3 times with ethyl acetate.The organic phases were combined and dried using 0.5 g anhydrous magnesium sulfate.filter,Steaming under reduced pressure to obtain a crude product.Finally, it is separated and purified by column chromatography.The column chromatography eluate used was a petroleum ether:ethyl acetate mixed solvent having a volume ratio of 40:1. Obtaining pure 6-(2-bromophenyl)indolo[1,2-a]quinoxaline,The yield is as high as 63%.
  • 2
  • [ 79477-87-5 ]
  • [ 473918-48-8 ]
  • 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With ammonium peroxydisulfate; palladium diacetate; In diethylene glycol dimethyl ether; at 78℃; for 12h;Green chemistry; 0.2 mmol of 2-(1H-indol-1-yl)aniline, 0.01 mmol of palladium acetate, 0.4 mmol of ammonium persulfate and 0.4 mmol of 3-fluorobenzoic acid were sequentially added to the reaction tube. Then, 2 ml of diethylene glycol dimethyl ether was added as a solvent, and the reaction was stirred at 78 C for 12 hours, the reaction was stopped, cooled to room temperature and filtered, and the filtrate was extracted with ethyl acetate three times, and the organic phase was combined and used. The organic layer was dried over anhydrous magnesium sulfate, filtered, and evaporated to dryness, and then evaporated, and then purified by column chromatography. The column chromatography was used as a mixture of petroleum ether and ethyl acetate in a volume ratio of 55:1. Pure 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline was obtained in a yield of up to 82%.
  • 3
  • [ 7194-78-7 ]
  • [ 473918-48-8 ]
  • 6-(3-bromophenyl)indolo[1,2-a]quinoxaline [ No CAS ]
 

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