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Chemical Structure| 486437-19-8 Chemical Structure| 486437-19-8

Structure of 486437-19-8

Chemical Structure| 486437-19-8

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Product Details of [ 486437-19-8 ]

CAS No. :486437-19-8
Formula : C10H8F3N
M.W : 199.17
SMILES Code : NCC#CC1=CC=C(C(F)(F)F)C=C1
MDL No. :MFCD12156086

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Application In Synthesis of [ 486437-19-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 486437-19-8 ]

[ 486437-19-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 109-02-4 ]
  • [ 486437-19-8 ]
  • [ 486437-06-3 ]
  • [ 68957-94-8 ]
  • [ 486434-91-7 ]
YieldReaction ConditionsOperation in experiment
71% In dichloromethane; Example 21 N-[3-(4-trifluoromethylphenyl)-prop-2-ynyl]-4-(4'-trifluoro-methylbiphenyl-2-carbonyl-amino)-1-methyl-imidazole-2-carboxylic acid amide Prepared analogously to Example 11 from 3-(4-trifluoromethylphenyl)-prop-2-ynylamine and 4-(4'-trifluoromethyl-biphenyl-2-carbonyl-amino)-1-methyl-imidazole-2-carboxylic acid in dichloromethane with the addition of propanephosphonic acid cycloanhydride and N-methyl-morpholine. Yield: 71% of theory Rf value: 0.49 (silica gel; dichloromethane/ethanol=9:1)
  • 2
  • [ 486437-19-8 ]
  • [ 486437-06-3 ]
  • [ 68957-94-8 ]
  • [ 486434-91-7 ]
YieldReaction ConditionsOperation in experiment
71% With 4-methyl-morpholine; In dichloromethane; EXAMPLE 21 N-[3-(4-trifluoromethylphenyl)prop-2-ynyl]-4-(4'-trifluoromethylbiphenyl-2-carbonyl-amino)-1-methylimidazole-2-carboxylic Acid Amide Prepared analogously to Example 11 from 3-(4-trifluoromethylphenyl)prop-2-ynylamine and 4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methylimidazole-2-carboxylic acid in dichloromethane with the addition of propanephosphonic acid cycloanhydride and N-methylmorpholine. Yield: 71% of theory; Rf value: 0.49 (silica gel; dichloromethane/ethanol 9:1); C29H20F6N4O2 (570.49); mass spectrum: (M-H)-569; (M+Na)+=593.
 

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