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CAS No.: 490-79-9
                                    
                                
 
                                 
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                            The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Gentisic acid is a natural product isolated and purified from the roots of Gentiana scabra Bunge.
Synonyms: Gentisic Acid; NSC 78825; NSC 49098
 
                
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        				*For Research Use Only !
        			
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Auxetic Liquid Crystal Elastomers: Overcoming Barriers to Scale-Up
Berrow, Stuart R ; Raistrick, Thomas ; Mandle, Richard J ; Gleeson, Helen F ;
Abstract: The observation of auxetic behaviour (i.e. negative Poisson’s ratio) in liquid crystal elastomers (LCEs) presents an exciting opportunity to explore application areas previously inaccessible to LCEs. Since its initial discovery, research has focused on improving understanding of the underpinning physics that drives the auxetic response, the structure-property relationships that enable the response to be tuned, and LCE properties such as the refractive index. However, the auxetic LCE materials reported to date have made use of either mechanical strain during fabrication, or unreactive ‘templates’ to stabilize the nematic ordering in the precursors. The latter approach provides excellent monodomain films, but there is unavoidable anisotropic shrinkage of the LCE. Both processes previously employed create complications towards manufacturing and scale-up. In this article, we report the first example of an auxetic LCE synthesized through surface alignment without the use of a non-reactive ‘template’ and thus without the need for a washout. The LCE includes both terminally and laterally attached mesogens, presents an auxetic threshold of 76% strain, and displays a comparable dependence of auxetic behaviour on its glass transition temperature as that reported in the literature. This work presents an exciting milestone in the journey towards realizing applications for auxetic LCEs.
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Keywords: Liquid crystal elastomer ; Auxetic ; Mechanical metamaterials ; Elastomer ; Network
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                        Hassan, Sara A ; Zaater, Marwa A ; Abdel-Rahman, Islam M ; Ibrahim, Elsayed A ; El Kerdawy, Ahmed M ; Abouelmagd, Sara A
Abstract: The development of new forms of existing APIs with enhanced physicochemical properties is critical for improving their therapeutic potential. In this context, ionic liquids (ILs) and deep eutectic solvents (DESs) have gained significant attention in recent years due to their unique properties and potential for solubility enhancement. In this study, we explore the role of different counterparts in the formation of IL/DESs with piperine (PI), a poorly water-soluble drug. After screening a library of fourteen counterpart molecules, ten liquid PI-counterpart systems were developed and investigated. Thermal analysis confirmed the formation of IL/DES, while computational and spectroscopic studies revealed that hydrogen bonding played a crucial role in the interaction between PI and the counterparts, confirming DES formation. The solubility enhancement of PI in these systems ranged from ∼ 36 % to 294 %, with PI-Oxalic acid (OA) exhibiting the highest saturation solubility (49.71 μg/mL) and PI-Ibuprofen (IB) the lowest (17.23 μg/mL). The presence of hydrogen bonding groups in counterparts was key to successful DES formation. A negative correlation was observed between solubility and logP (r = − 0.75, p* = 0.0129), while a positive correlation was found between solubility and normalized polar surface area (PSA) (r = 0.68, p* = 0.029). PI-OA and PI-IB were located at the extreme ends of these regression lines, further validating the relationship between these properties and solubility enhancement. These findings highlight essential aspects of rational IL/DES design, optimizing their properties for broader applications.
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                        | CAS No. : | 490-79-9 | 
| Formula : | C7H6O4 | 
| M.W : | 154.12 | 
| SMILES Code : | OC(=O)C1=C(O)C=CC(O)=C1 | 
| Synonyms : | 
                                Gentisic Acid; NSC 78825; NSC 49098
                             | 
| MDL No. : | MFCD00002460 | 
| InChI Key : | WXTMDXOMEHJXQO-UHFFFAOYSA-N | 
| Pubchem ID : | 3469 | 
| GHS Pictogram: |   | 
| Signal Word: | Warning | 
| Hazard Statements: | H302-H315-H319-H335 | 
| Precautionary Statements: | P261-P305+P351+P338 | 
In Vitro:
| Cell Line | Concentration | Treated Time | Description | References | 
| HepG2 cells | 0.001, 0.01, 0.1, 1, 10 μM | 24 h | To evaluate the effect of 2,5-DHBA on oleic acid-induced lipid accumulation in HepG2 cells. Results showed that 2,5-DHBA significantly reduced lipid accumulation in a dose-dependent manner without affecting cell viability. | Nutrients. 2025 May 28;17(11):1835 | 
In Vivo:
| Species | Animal Model | Administration | Dosage | Frequency | Description | References | 
| Mice | Bdh2 null mice | Intraperitoneal injection | 500 mg/kg | Two doses, 24 hours apart, sacrificed 24 hours after last injection | Supplementation with 2,5-DHBA alleviates splenic iron overload in bdh2 null mice | Mol Cell Biol. 2014 Jul;34(13):2533-46 | 
| FVB mice | High-fat diet-induced MASLD mouse model | Oral gavage | 1, 10, 100 mg/kg | Once daily for 7 days (short-term experiment) or 4 weeks (long-term experiment) | To evaluate the effect of 2,5-DHBA on hepatic lipid accumulation in HFD-induced MASLD mice. Results showed that 2,5-DHBA significantly reduced hepatic lipid accumulation in a dose-dependent manner and improved liver histology. | Nutrients. 2025 May 28;17(11):1835 | 
Tags: 2,5-Dihydroxybenzoic acid | Endogenous Metabolite | FGFR | Fibroblast growth factor receptor | 490-79-9 |
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