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Chemical Structure| 491871-36-4 Chemical Structure| 491871-36-4

Structure of 491871-36-4

Chemical Structure| 491871-36-4

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Product Details of [ 491871-36-4 ]

CAS No. :491871-36-4
Formula : C13H12N2O4
M.W : 260.25
SMILES Code : O=CC1=CC=C(OC2=NC(OC)=CC(OC)=N2)C=C1
MDL No. :MFCD02956679

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Application In Synthesis of [ 491871-36-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 491871-36-4 ]

[ 491871-36-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 123-08-0 ]
  • [ 5270-94-0 ]
  • [ 491871-36-4 ]
YieldReaction ConditionsOperation in experiment
87% With potassium carbonate; In acetonitrile; at 80 - 85℃; Added 0.01mol (2.18g) 4,6- dimethoxy pyrimidine, 0.011mol (1.34g) hydroxybenzaldehyde with 125mL anhydrous acetonitrile was dissolved in 250mL three-necked flask, followed by the addition of carbonate drying small study potassium powder 1.38g (0.1mol), 80 ~ 85 heated to reflux, TLC monitoring of the reaction, the end of the reaction about 4-5 hours. The reaction liquid was cooled to room temperature, the solvent off most of the acetonitrile, 100mL of ethyl acetate was added to the system, the system was 50 mL water solids (potassium carbonate) dissolved in the organic phase washed with water and continue (50mL × 2), the combined aqueous phases, 20mL ethyl acetate three times. The combined organic phase was dried over anhydrous sodium sulfate. Filtered off the solvent to give a light brown oil. Silica gel column chromatography, eluent ethyl acetate: petroleum ether = 1/4, as a white solid. Yield 87%
 

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