[ CAS No. 5270-94-0 ] {[proInfo.proName]}

Name: 5270-94-0|4,6-Dimethoxypyrimidine|97%
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Quality Control of [ 5270-94-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 5270-94-0 ]

Product Details of [ 5270-94-0 ]

CAS No. :	5270-94-0	MDL No. :	MFCD00955844
Formula :	C₆H₈N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FPSPPRZKBUVEJQ-UHFFFAOYSA-N
M.W :	140.14	Pubchem ID :	259821
Synonyms :

Calculated chemistry of [ 5270-94-0 ]

Physicochemical Properties

Num. heavy atoms :	10
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.33
Num. rotatable bonds :	2
Num. H-bond acceptors :	4.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.02
TPSA :	44.24 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.47 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.57
Log Po/w (XLOGP3) :	0.96
Log Po/w (WLOGP) :	0.49
Log Po/w (MLOGP) :	-0.11
Log Po/w (SILICOS-IT) :	0.85
Consensus Log Po/w :	0.75

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.63
Solubility :	3.32 mg/ml ; 0.0237 mol/l
Class :	Very soluble
Log S (Ali) :	-1.48
Solubility :	4.68 mg/ml ; 0.0334 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.88
Solubility :	1.84 mg/ml ; 0.0132 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.72

Safety of [ 5270-94-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 5270-94-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5270-94-0 ]
Downstream synthetic route of [ 5270-94-0 ]

[ 5270-94-0 ] Synthesis Path-Upstream 1~5

1
[ 1193-21-1 ]
[ 124-41-4 ]
[ 5270-94-0 ]

Reference： [1] Patent: US2006/287341, 2006, A1, . Location in patent: Page/Page column 41

2
[ 13223-25-1 ]
[ 128276-49-3 ]
[ 5270-94-0 ]

Reference： [1] Tetrahedron, 1999, vol. 55, # 2, p. 405 - 412

3
[ 75-09-2 ]
[ 584-08-7 ]
[ 2258-42-6 ]
[ 5270-94-0 ]

Reference： [1] Patent: US5276152, 1994, A,

4
[ 5270-94-0 ]
[ 4319-77-1 ]

Reference： [1] Patent: US2006/287341, 2006, A1, . Location in patent: Page/Page column 41

5
[ 5270-94-0 ]
[ 74-88-4 ]
[ 13566-63-7 ]

Reference： [1] Journal of Organic Chemistry, 1990, vol. 55, # 10, p. 3410 - 3412

[ 5270-94-0 ] Synthesis Path-Downstream 1~25

1
[ 100-52-7 ]
[ 5270-94-0 ]
[ 126327-70-6 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412

2
[ 98-88-4 ]
[ 5270-94-0 ]
[ 126327-71-7 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412

3
[ 75-77-4 ]
[ 5270-94-0 ]
[ 126327-69-3 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412

4
[ 5270-94-0 ]
[ 74-88-4 ]
[ 13566-63-7 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 3410 - 3412

5
[ 5270-94-0 ]
[ 97984-28-6 ]

Reference： [1]Heterocycles,1985,vol. 23,p. 1077 - 1080
[2]Journal of Organic Chemistry,1986,vol. 51,p. 4623 - 4626
[3]Heterocycles,1985,vol. 23,p. 1077 - 1080

6
[ 13223-25-1 ]
[ 128276-49-3 ]
[ 5270-94-0 ]

Reference： [1]Tetrahedron,1999,vol. 55,p. 405 - 412

9
diimidate [ No CAS ]
ethereal ammonia [ No CAS ]
aqueous K₂ CO₃ [ No CAS ]
acetyl choloride [ No CAS ]
dimethyl-1,3-propanediimidate dihydrochloride [ No CAS ]
[ 75-09-2 ]
[ 584-08-7 ]
[ 2258-42-6 ]
[ 5270-94-0 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonia; sodium formate; In diethyl ether; water;	EXAMPLE 1 4,6-Dimethoxypyrimidine 5.0 g of dimethyl-1,3-propanediimidate dihydrochloride was added by vigorous stirring to a mixture of 25 ml of CH2 Cl2 and 25 ml of aqueous K2 CO3 solution (300 g of K2 CO3 /1 solution). After 5 minutes the organic phase was separated and the aqueous phase was extracted with 10 ml of Ch2 Cl2. The combined organic phases were dried on Na2 SO4 and filtered. A freshly prepared mixture of 2.5 g of formyl acetate [produced from acetyl choloride and sodium formate according to Muramatsu et al., Bull. Chem. Soc., Japan, 38, (1965), p. 244] in 2 ml of diethyl ether was added at 0 C. to the above solution of the diimidate and stirred for two hours at this temperature. A small amount of ammonia gas was introduced (or ethereal ammonia solution was added) so that the reaction mixture showed an approximately neutral reaction with moistened pH paper. After another hour of stirring at 0 C., 10 ml of water was added. The organic phase was separated, dried on Na2 SO4 and gently concentrated by evaporation. After distillation in a bulb tube furnace (product fraction: 110 C./16 mbar) the product was obtained as a colorless oil, which gradually solidified when allowed to stand. The yield of the product was: 2.4 g, which was 66.3 percent relative to the dihydrochloride used with a product content of 96 percent (GC).

Reference： [1]Patent: US5276152,1994,A

10
[ 5270-94-0 ]
[ 4319-77-1 ]

Yield	Reaction Conditions	Operation in experiment
	With N-Bromosuccinimide; acetic anhydride; at 100.0℃; for 5.16h;	B. Preparation of 5-bromo-<strong>[5270-94-0]4,6-dimethoxypyrimidine</strong> To the solution of <strong>[5270-94-0]4,6-dimethoxypyrimidine</strong> (5 g, 35.7 mmol) in HOAc (20 mL) at room temperature under argon was added Ac2O (4.6 g, 44.6 mmol). The resulting solution was heated at 100 C. for 10 min and then NBS (7.9 g, 44.6 mmol) was added. Heating was continued at 100 C. for 5 h. Analysis by HPLC/MS indicated that the reaction was complete. After the reaction mixture was cooled to room temperature, water (50 mL) was added. The resulting precipitate was collected by filtration and further washed with water (15 mL*3), then dried under vacuum. The title compound (7.5 g) was obtained as a white solid. 1H NMR (CDCl3): delta 4.05 (s, 6H), 8.32 (s, 1H). 13C NMR (CDCl3): delta 55.2, 89.0, 154.9, 166.8.

Reference： [1]Patent: US2006/287341,2006,A1 .Location in patent: Page/Page column 41

11
[ 1193-21-1 ]
[ 124-41-4 ]
[ 5270-94-0 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 20 - 65℃; for 24.08h;	Preparation of Intermediate 4-chloro-6-(4-chlorophenyl)-5-(pyridin-4-yl)pyrimidine; A. Preparation of 4,6-dimethoxypyrimidine; To a suspension of 4,6-dichloropyrimidine (6.5 g, 43.9 mmol) in methanol (30 mL) at room temperature under argon was added NaOMe (7.1 g, 132 mmol) over 5 min. The resulting suspension was heated at 65 C. under argon for 24 h. Analysis by HPLC/MS indicated that the reaction was complete. Most of the solvent was removed under reduced pressure, then 1 M aqueous HCl (50 mL) and CH2Cl2 (50 mL) were added to the residue. The layers were separated and the organic phase was washed with saturated aqueous NaCl (30 mL), then dried (Na2SO4), filtered and evaporated. The crude product was purified by silica gel column chromatography eluted with ethyl acetate-hexanes to obtain the title compound (5.76 g) as a low melting solid. See also Synthesis 1998, page 36.

Reference： [1]Patent: US2006/287341,2006,A1 .Location in patent: Page/Page column 41

12
[ 5270-94-0 ]
5-iodo-4,6-dimethoxypyrimidine [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 6776 - 6780
Angew. Chem.,2013,p. 6909 - 6913

13
[ 1521-51-3 ]
[ 5270-94-0 ]
2-(cyclohex-2-en-1-yl)-4,6-dimethoxypyrimidine [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 6776 - 6780
Angew. Chem.,2013,p. 6909 - 6913

14
[ 696-62-8 ]
[ 5270-94-0 ]
4,6-dimethoxy-2-(4-methoxyphenyl)pyrimidine [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 6776 - 6780
Angew. Chem.,2013,p. 6909 - 6913

15
[ 1296137-49-9 ]
[ 5270-94-0 ]
5-(trans-2-((tert-butyldimethylsilyl)oxy)cyclohexyl)-4,6-dimethoxypyrimidine [ No CAS ]

Reference： [1]Organic Letters,2014,vol. 16,p. 6500 - 6503

16
TMG•CF₃I [ No CAS ]
[ 5270-94-0 ]
4,6-dimethoxy-5-(trifluoromethyl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With dipotassium peroxodisulfate; copper(II) acetate monohydrate; acetic acid; at 90℃; for 24h;Inert atmosphere; Sealed tube;	[00238] <strong>[5270-94-0]4,6-Dimethoxypyrimidin</strong>e (35.0 mg, 0.250 mmol, 1.00 eq), K2S20g (270 mg, 1.00 mmol, 4.00 eq) and Cu(OAc)2 FontWeight="Bold" FontSize="10" H20 (100 mg, 0.500 mmol, 2.00 eq) were dissolved in glacial acetic acid (2.00 mL). TMG FontWeight="Bold" FontSize="10" CF3I (0.100 mL, 0.500 mmol, 2.00 eq) was added, the reaction vessel was sealed and heated at 90 C for 24 hours. The reaction mixture was diluted with saturated aqueous sodium carbonate (50 mL) and the resulting mixture extracted with ethyl acetate (3 x 25 mL). The combined ethyl acetate extracts were dried (MgS04) and concentrated in vacuo. The residue was purified by preparative TLC eluting with 10% EtOAc/hexanes to afford 26.0 mg (0.125 mmol, 50%) 14 as a white solid. [00239] R/= 0.55 (10% EtOAc/hexanes). NMR spectroscopy: 1H NMR (400 MHz, CDC13, 23 C) delta ppm 8.48 (s, 1H), 4.05 (s, 6H). 13C NMR (125 MHz, CDC13, 23 C) delta ppm 167.9, 158.8, 122.8 (q, JCF = 273 Hz), 95.5 (q, JCF = 35 Hz), 55.1. 19F NMR (376 MHz, CDC13, 23 C) delta ppm -56.9. Mass spectrometry: HRMS (APCI) (m/z): Calcd for [C7H7F3N202]+, [M+]: 208.0460. Found, 208.0466.

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 3712 - 3716
Angew. Chem.,2015,vol. 127,p. 3783 - 3787,5
[2]Patent: WO2015/168368,2015,A1 .Location in patent: Paragraph 00238; 00239

17
TMG•CF₃CF₂I [ No CAS ]
[ 5270-94-0 ]
4,6-dimethoxy-5-(pentafluoroethyl)pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With dipotassium peroxodisulfate; copper(II) acetate monohydrate; acetic acid; at 90℃; for 24h;Inert atmosphere; Sealed tube;	[00240] <strong>[5270-94-0]4,6-Dimethoxypyrimidin</strong>e (35.0 mg, 0.250 mmol, 1.00 eq), K2S208 (270 mg, 1.00 mmol, 4.00 eq) and Cu(OAc)2 FontWeight="Bold" FontSize="10" H20 (100 mg, 0.500 mmol, 2.00 eq) were dissolved in glacial acetic acid (2.00 mL). TMG FontWeight="Bold" FontSize="10" CF3CF2I (0.110 mL, 0.500 mmol, 2.00 eq) was added, the reaction vessel was sealed and heated at 90 C for 24 hours. The reaction mixture was diluted with saturated aqueous sodium carbonate (50 mL) and the resulting mixture extracted with ethyl acetate (3 x 25 mL). The combined ethyl acetate extracts were dried (MgS04) and concentrated in vacuo. The residue was purified by preparative TLC eluting with 10% EtOAc/hexanes to afford 33.1 mg (0.128 mmol, 51%) 15 as a white solid. [00241] R/= 0.58 (10% EtOAc/hexanes). NMR spectroscopy: 1H NMR (400 MHz, CDC13, 23 C) delta ppm 8.47 (s, 1H), 4.01 (s, 6H). 13C NMR (125 MHz, CDC13, 23 C) delta ppm 168.9, 159.2, 119.4 (qt, JCF = 288, 39 Hz), 112.7 (tq, JCF = 258, 41 Hz), 93.3 (t, JCF = 24 Hz), 55.0. 19F NMR (376 MHz, CDC13, 23 C) delta ppm -85.0 (s, 3F), -110.6 (s, 2F). Mass spectrometry: HRMS (APCI) (m/z): Calcd for [C8H7F5N202]+, [M+]: 258.0428. Found, 258.0434.

18
[ 5270-94-0 ]
(3E,5E)-3,5-bis({4-[(4,6-dimethoxypyrimidin-2-yl)oxy]phenyl}methylidene)-1-methylpiperidin-4-one [ No CAS ]

Reference： [1]Patent: CN105481781,2016,A

19
[ 5270-94-0 ]
(2E,5E)-2,5-bis({4-[(4,6-dimethoxypyrimidin-2-yl)oxy]phenyl}methylidene)cyclopentan-1-one [ No CAS ]

Reference： [1]Patent: CN105481781,2016,A

20
[ 123-08-0 ]
[ 5270-94-0 ]
[ 491871-36-4 ]

Yield	Reaction Conditions	Operation in experiment
87%	With potassium carbonate; In acetonitrile; at 80 - 85℃;	Added 0.01mol (2.18g) 4,6- dimethoxy pyrimidine, 0.011mol (1.34g) hydroxybenzaldehyde with 125mL anhydrous acetonitrile was dissolved in 250mL three-necked flask, followed by the addition of carbonate drying small study potassium powder 1.38g (0.1mol), 80 ~ 85 heated to reflux, TLC monitoring of the reaction, the end of the reaction about 4-5 hours. The reaction liquid was cooled to room temperature, the solvent off most of the acetonitrile, 100mL of ethyl acetate was added to the system, the system was 50 mL water solids (potassium carbonate) dissolved in the organic phase washed with water and continue (50mL × 2), the combined aqueous phases, 20mL ethyl acetate three times. The combined organic phase was dried over anhydrous sodium sulfate. Filtered off the solvent to give a light brown oil. Silica gel column chromatography, eluent ethyl acetate: petroleum ether = 1/4, as a white solid. Yield 87%

Reference： [1]Patent: CN105481781,2016,A .Location in patent: Paragraph 0032; 0035

21
[ 121-33-5 ]
[ 5270-94-0 ]
4-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxybenzaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
28%	With sodium carbonate; In N,N-dimethyl-formamide; at 120℃;	Was added 0.01mol (1.86g) 4,6- dimethyl sulfoxide pyrimidine, 0.022mol (3.34g) 3- methoxy-4-hydroxybenzaldehyde in a 250mL three-necked flask, dissolved with 125mL dry DMF , followed by the addition of sodium carbonate powder drying fine grind 1.38g (0.1mol), 120 heated to reflux, TLC monitoring of the reaction, the end of the reaction is about 10 to 15 hours. Thereto were added 300mL of water, and then extracted three times with 100mL ethyl acetate and the combined organic phase was dried over anhydrous sodium sulfate. Filtered off the solvent to give a light brown oil. Silica gel column chromatography, eluent ethyl acetate: petroleum ether = 1/4, as a white solid. Yield 28%

Reference： [1]Patent: CN105481781,2016,A .Location in patent: Paragraph 0085; 0086

22
[ 15315-02-3 ]
[ 5270-94-0 ]
C₉H₇F₇N₂O₂ [ No CAS ]

Reference： [1]ACS Catalysis,2018,vol. 8,p. 2839 - 2843

23
[ 14353-88-9 ]
[ 5270-94-0 ]
4,6-dimethoxy-5-(trifluoromethyl)pyrimidine [ No CAS ]

Reference： [1]ACS Catalysis,2018,vol. 8,p. 2839 - 2843

24
[ 358-23-6 ]
[ 5270-94-0 ]
4,6-dimethoxy-5-(trifluoromethyl)pyrimidine [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2018,vol. 57,p. 6926 - 6929
Angew. Chem.,2018,vol. 130,p. 7042 - 7045,4

25
[ 2926-29-6 ]
[ 5270-94-0 ]
4,6-dimethoxy-5-(trifluoromethyl)pyrimidine [ No CAS ]

Reference： [1]Chemistry - A European Journal,2020,vol. 26,p. 3241 - 3246

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
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Code	Phrase
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P321
P322
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P390	Absorb spillage to prevent material damage.
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P401
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P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 5270-94-0 ] {[proInfo.proName]}

Quality Control of [ 5270-94-0 ]

Related Doc. of [ 5270-94-0 ]

Product Details of [ 5270-94-0 ]

Calculated chemistry of [ 5270-94-0 ]

Physicochemical Properties

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Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 5270-94-0 ]

Application In Synthesis of [ 5270-94-0 ]

[ 5270-94-0 ] Synthesis Path-Upstream 1~5

[ 5270-94-0 ] Synthesis Path-Downstream 1~25

Related Functional Groups of [ 5270-94-0 ]

Ethers

Related Parent Nucleus of [ 5270-94-0 ]

Pyrimidines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 5270-94-0 ]

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[ 5270-94-0 ]