[ CAS No. 4919-37-3 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 4919-37-3
Chemical Structure| 4919-37-3
Structure of 4919-37-3

Quality Control of [ 4919-37-3 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 4919-37-3 ]

SDS

Product Details of [ 4919-37-3 ]

CAS No. :4919-37-3MDL No. :MFCD00016536
Formula :C9H10O3Boiling Point :331.3°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :166.17Pubchem ID :138387
Synonyms :

Computed Properties of [ 4919-37-3 ]

TPSA : 57.5 H-Bond Acceptor Count : 3
XLogP3 : - H-Bond Donor Count : 2
SP3 : 0.22 Rotatable Bond Count : 1

Safety of [ 4919-37-3 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4919-37-3 ]

  • Upstream synthesis route of [ 4919-37-3 ]

[ 4919-37-3 ] Synthesis Path-Upstream   1~15

  • 1
  • [ 67-56-1 ]
  • [ 99-96-7 ]
  • [ 4919-37-3 ]
YieldReaction ConditionsOperation in experiment
85% at 40 - 60℃; Microwave irradiation (1) in 500 ml in the reaction bottle, to join the hydroxy benzoic acid 138g (1 µM), adding methanol 160g (5 µM), solid acid 50g, stirring to a solid uniform. In putting into ultrasonic reactor, and is additionally provided with a return device, the reaction temperature is 40 - 60 °C, ultrasonic power 500W, reaction 1 - 3h, reaction solution gradually changed from white to yellow, and then into orange red. HPLC tracking the conversion rate of the reaction, the reaction to the hydroxy benzoic acid is less than 5percent the following calculating the reaction is complete, stopping the reaction, filtering of the solid acid catalyst, the catalyst can be applied to the next reaction; the filter placed about 5 - 10 °C crystalline 6 - 10h, the crystal filter, 50 - 60 °C drying 6h, HPLC detection, impurities less than 0.1percent, to obtain the intermediate 4 - hydroxy - 3, 5 - dimethyl benzoic acid 141g, yield is 85percent.
Reference: [1] Patent: CN106588576, 2017, A. Location in patent: Paragraph 0074-0080
  • 2
  • [ 124-38-9 ]
  • [ 10570-67-9 ]
  • [ 4919-37-3 ]
Reference: [1] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5382 - 5385
  • 3
  • [ 21553-46-8 ]
  • [ 4919-37-3 ]
Reference: [1] Bulletin of the Chemical Society of Japan, 2007, vol. 80, # 10, p. 2008 - 2010
[2] Comment. phys. math., 1956, vol. 19, # 1, p. 38
  • 4
  • [ 97888-80-7 ]
  • [ 4919-37-3 ]
Reference: [1] Synthetic Communications, 1995, vol. 25, # 10, p. 1433 - 1439
  • 5
  • [ 201230-82-2 ]
  • [ 10570-67-9 ]
  • [ 4919-37-3 ]
Reference: [1] Angewandte Chemie - International Edition, 2010, vol. 49, # 10, p. 1867 - 1870
  • 6
  • [ 4919-40-8 ]
  • [ 4919-37-3 ]
Reference: [1] Chemische Berichte, 1879, vol. 12, p. 607[2] Chemische Berichte, 1888, vol. 21, p. 2829
[3] Journal of the American Chemical Society, 1948, vol. 70, p. 317
  • 7
  • [ 576-26-1 ]
  • [ 4919-37-3 ]
Reference: [1] Journal of Medicinal Chemistry, 2006, vol. 49, # 17, p. 5382 - 5385
  • 8
  • [ 80238-12-6 ]
  • [ 4919-37-3 ]
Reference: [1] Journal of the American Chemical Society, 1948, vol. 70, p. 317
  • 9
  • [ 576-26-1 ]
  • [ 124-38-9 ]
  • [ 4919-37-3 ]
Reference: [1] Synlett, 2006, # 10, p. 1543 - 1546
[2] Journal of medicinal and pharmaceutical chemistry, 1960, vol. 2, p. 201 - 212
  • 10
  • [ 1446750-47-5 ]
  • [ 4919-37-3 ]
Reference: [1] Helvetica Chimica Acta, 2013, vol. 96, # 6, p. 1176 - 1181
  • 11
  • [ 2233-18-3 ]
  • [ 4919-37-3 ]
Reference: [1] Monatshefte fuer Chemie, 1950, vol. 81, p. 1071,1083
  • 12
  • [ 83037-98-3 ]
  • [ 4919-37-3 ]
Reference: [1] Comment. phys. math., 1956, vol. 19, # 1, p. 38
  • 13
  • [ 527-60-6 ]
  • [ 4919-37-3 ]
  • [ 6245-04-1 ]
Reference: [1] Justus Liebigs Annalen der Chemie, 1881, vol. 206, p. 175
  • 14
  • [ 124-38-9 ]
  • [ 16081-16-6 ]
  • [ 4919-37-3 ]
Reference: [1] Monatshefte fuer Chemie, 1950, vol. 81, p. 1071,1083
  • 15
  • [ 4919-40-8 ]
  • [ 7782-77-6 ]
  • [ 4919-37-3 ]
Reference: [1] Chemische Berichte, 1879, vol. 12, p. 607[2] Chemische Berichte, 1888, vol. 21, p. 2829
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