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Chemical Structure| 179897-94-0 Chemical Structure| 179897-94-0
Chemical Structure| 179897-94-0

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Product Details of 5-Fluoro-2-methoxyphenylboronic acid

CAS No. :179897-94-0
Formula : C7H8BFO3
M.W : 169.95
SMILES Code : OB(C1=CC(F)=CC=C1OC)O
MDL No. :MFCD01863526
InChI Key :CCQKIRUMTHHPSX-UHFFFAOYSA-N
Pubchem ID :2782673

Safety of 5-Fluoro-2-methoxyphenylboronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 5-Fluoro-2-methoxyphenylboronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 179897-94-0 ]

[ 179897-94-0 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 122135-83-5 ]
  • [ 179897-94-0 ]
  • [ 654075-20-4 ]
  • 2
  • [ 179897-94-0 ]
  • [ 72955-97-6 ]
  • 3
  • [ 10323-39-4 ]
  • [ 179897-94-0 ]
  • [ 1609538-42-2 ]
  • 4
  • [ 92001-52-0 ]
  • [ 179897-94-0 ]
  • 6-(5-fluoro-2-methoxyphenyl)-8-methyl-9H-purine [ No CAS ]
  • 5
  • [ 118289-17-1 ]
  • [ 179897-94-0 ]
  • 2-(5-fluoro-2-methoxyphenyl)isonicotinaldehyde [ No CAS ]
YieldReaction ConditionsOperation in experiment
83.4% General procedure: To a 50 mL two-necked flask equipped with magnetic stirrer and condenser was added 2-bromopyridine (1.0 eq), Pd(PPh3)4 (5 mol%), K2CO3 solution (2.0 eq) and toluene under N2 at room temperture. After reacted for 15 min, a solution of the boronic acid (1.2 eq) in EtOH was then added. The reaction mixture was then heated to 95 C and reacted for 4 h. After cooling to room temperature, to the reaction mixture aqueous NH4Cl was added and extracted three times with EtOAc. The organic extracts were then combined, washed with brine, dried with MgSO4 and then concentrated under reduced pressure. The crude product was then purified by silica gel column chromatography(Petroleum ether/EtOAc) to give compounds 1 and 5
 

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