Home Cart Sign in  
Chemical Structure| 1072-67-9 Chemical Structure| 1072-67-9
Chemical Structure| 1072-67-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Synonyms: 5-Methyl-1,2-oxazol-3-amine

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of 5-Methylisoxazol-3-amine

CAS No. :1072-67-9
Formula : C4H6N2O
M.W : 98.10
SMILES Code : CC1=CC(N)=NO1
Synonyms :
5-Methyl-1,2-oxazol-3-amine
MDL No. :MFCD00003155
InChI Key :FKPXGNGUVSHWQQ-UHFFFAOYSA-N
Pubchem ID :66172

Safety of 5-Methylisoxazol-3-amine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 5-Methylisoxazol-3-amine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1072-67-9 ]
  • Downstream synthetic route of [ 1072-67-9 ]

[ 1072-67-9 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1072-67-9 ]
  • [ 121-60-8 ]
  • [ 21312-10-7 ]
YieldReaction ConditionsOperation in experiment
59% at 20℃; for 12 h; A mixture of 4-acetamidobenzene-1-sulfonyl chloride (4.27 mmol), 5-methylisoxazol-3-amine (4.49 mmol) and DMAP (0.21 mmol) in anhydrous pyridine (10 mL) was stirred at room temperature for 12 h.
After completion of reaction, solvent was evaporated to dryness and diluted with water and extracted with ethyl acetate.
The combined organic layers were washed with water and 1 M aqueous HCl, dried over anhydrous Na2SO4, filtered, and concentrated under vacuum.
The solid residue obtained was purified with flash column chromatography using heptanes to EtOAc (50-100percent) gradient elution to afford the compound 2. 4.2.1
N-(4-(N-(5-Methylisoxazol-3-yl)sulfamoyl)phenyl)acetamide (2)
Yield: 59percent; ESIMS m/z calcd for C12H13N3O4S [M + H]+, 296.07; found 296.06; 1H NMR (400 MHz, (CD3)2SO): δ 11.30 (bs, 1H), 10.35 (bs, 1H), 7.79-7.73 (m, 4H), 6.12 (s, 1H), 2.29 (s, 3H), 2.07 (s, 3H).
13C (100 MHz, (CD3)2SO): δ 170.71, 169.57, 158.07, 144.01, 133.36, 128.50, 119.15, 95.84, 24.57, 12.48.
References: [1] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 1, p. 12 - 17.
[2] European Journal of Medicinal Chemistry, 2015, vol. 101, p. 595 - 603.
[3] Shionogi Kenkyusho Nenpo, 1957, # 7, p. 301,304[4] Chem.Abstr., 1957, p. 17889.
[5] Patent: US2888455, 1957, , .
[6] Crystal Growth and Design, 2013, vol. 13, # 9, p. 4002 - 4016.
[7] Patent: CN105884705, 2016, A, . Location in patent: Paragraph 0013; 0016; 0021; 0026; 0031.
 

Historical Records

Technical Information

Categories