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Chemical Structure| 5000-66-8 Chemical Structure| 5000-66-8

Structure of 5000-66-8

Chemical Structure| 5000-66-8

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Product Details of [ 5000-66-8 ]

CAS No. :5000-66-8
Formula : C8H6BrClO
M.W : 233.49
SMILES Code : O=C(CBr)C1=CC=CC=C1Cl
MDL No. :MFCD00832993
InChI Key :WZWWEVCLPKAQTA-UHFFFAOYSA-N
Pubchem ID :2735785

Safety of [ 5000-66-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H402
Precautionary Statements:P273-P280-P305+P351+P338-P310
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 5000-66-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5000-66-8 ]

[ 5000-66-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 17356-08-0 ]
  • [ 5000-66-8 ]
  • [ 21344-90-1 ]
YieldReaction ConditionsOperation in experiment
884 mg In ethanol; for 2h;Reflux; General procedure: The crude 2-bromo-1-(2-chlorophenyl)ethanone (0.64 mL, 4.28 mmol) was dissolved in anhydrous ethanol (10 mL) and treated with thiourea (344 mg, 4.51 mmol). After heating at reflux for 2 h, the reaction mixture was cooled to room temperature, with a yellow precipitation. The solid obtained was filtered, washed with water and ethanol and vacuum dried to afford 4b as a yellow solid (884 mg, 98.0percent). 1H NMR (CDCl3, 400 MHz): delta 7.12 (s, 1H), 7.46-7.55 (m, 2H), 7.62 (s, 1H), 7.63 (d, 1H, J = 1.2 Hz), 8.94 (s, 1H), 9.15 (s, 1H).
  • 2
  • [ 35553-92-5 ]
  • [ 69922-39-0 ]
  • [ 5000-66-8 ]
  • (5-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-(3-methoxyphenyl)-thiophen-2-yl)(2-chlorophenyl)methanone [ No CAS ]
  • 3
  • [ 30748-47-1 ]
  • [ 5000-66-8 ]
  • 1-(6-(2-chlorophenyl)-3-methylimidazo[2,1-b]thiazol-2-yl)ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With polyethylene glycol (PEG-400); In water; for 0.1h;Microwave irradiation; Green chemistry; To stirred solution of polyethylene glycol (PEG-400) (2 mL) in water (2 mL) were added 1-(2-amino-4-methylthiazol-5-yl)ethanone (2 mmol)/ethyl 2-amino-4-methylthiazole-5-carboxylate (2 mmol) and α-bromo aralkyl ketones (phenacyl bromides) (2 mmol), and the mixture was heated at 90 C or subject to microwave irradiation at 300 W, until reaction completion as indicated by TLC. After reaction completion, the reaction mixture was cooled at room temperature, and the solid product formed was collected by filtration, washed with water, and recrystallized from ethanol to give pure product. The recovered PEG with water was reused for five further cycles.
  • 4
  • [ 7210-76-6 ]
  • [ 5000-66-8 ]
  • ethyl 6-(2-chlorophenyl)-3-methylimidazo[2,1-b]thiazole-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With polyethylene glycol (PEG-400); In water; for 0.116667h;Microwave irradiation; Green chemistry; To stirred solution of polyethylene glycol (PEG-400) (2 mL) in water (2 mL) were added 1-(2-amino-4-methylthiazol-5-yl)ethanone (2 mmol)/ethyl 2-amino-4-methylthiazole-5-carboxylate (2 mmol) and α-bromo aralkyl ketones (phenacyl bromides) (2 mmol), and the mixture was heated at 90 C or subject to microwave irradiation at 300 W, until reaction completion as indicated by TLC. After reaction completion, the reaction mixture was cooled at room temperature, and the solid product formed was collected by filtration, washed with water, and recrystallized from ethanol to give pure product. The recovered PEG with water was reused for five further cycles.
 

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