Alternatived Products of [ 500770-77-4 ]
Product Details of [ 500770-77-4 ]
CAS No. : | 500770-77-4 |
MDL No. : | MFCD03427925 |
Formula : |
C15H18F3NO4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | DYZRXQICSTZZKP-NSHDSACASA-N |
M.W : |
333.30
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Pubchem ID : | 7023295 |
Synonyms : |
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Safety of [ 500770-77-4 ]
Application In Synthesis of [ 500770-77-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 500770-77-4 ]
- 1
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[ 500770-77-4 ]
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[ 109-85-3 ]
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[ 1366063-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
80% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 15h; |
40.A tert-Butyl {(1S)-3-[(2-methoxyethyl)amino]-3-oxo-1-[2-(trifluoromethyl)phenyl]propyl}carbamate
Example 40A tert-Butyl {(1S)-3-[(2-methoxyethyl)amino]-3-oxo-1-[2-(trifluoromethyl)phenyl]propyl}carbamate Analogously to Example 32A, but with a reaction time of 15 h, 142 mg (0.43 mmol) of (3S)-3-[(tert-butoxycarbonyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid and 38 mg (0.51 mmol) of 2-methoxyethanamine gave 133 mg (80% of theory) of the title compound. LC-MS [Method 1]: Rt=1.76 min; MS [ESIpos]: m/z=391 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): δ [ppm]=1.32 (s, 9H), 2.23-2.35 (m, 2H), 3.13-3.25 (m, 2H), 3.23 (s, 3H), 3.30 (t, 2H), 5.19-5.30 (m, 1H), 7.40-7.52 (m, 2H), 7.62-7.70 (m, 3H), 7.76 (br. t, 1H). |
- 2
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[ 500770-77-4 ]
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[ 141-43-5 ]
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[ 1366063-08-2 ]
Yield | Reaction Conditions | Operation in experiment |
86% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 15h; |
38.A tert-Butyl {(1S)-3-[(2-hydroxyethyl)amino]-3-oxo-1-[2-(trifluoromethyl)phenyl]propyl}carbamate
Example 38A tert-Butyl {(1S)-3-[(2-hydroxyethyl)amino]-3-oxo-1-[2-(trifluoromethyl)phenyl]propyl}carbamate Analogously to Example 32A, but with a reaction time of 15 h, 150 mg (0.45 mmol) of (3S)-3-[(tert-butoxycarbonyl)amino]-3-[2-(trifluoromethyl)phenyl]propanoic acid and 33 mg (0.54 mmol) of 2-aminoethanol gave 146 mg (86% of theory) of the title compound. LC-MS [Method 1]: Rt=1.53 min; MS [ESIpos]: m/z=377 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): δ [ppm]=1.32 (s, 9H), 2.24-2.34 (m, 2H), 3.02-3.19 (m, 2H), 3.34-3.41 (m, 2H), 4.64 (t, 1H), 5.20-5.30 (m, 1H), 7.39-7.55 (m, 2H), 7.61-7.73 (m, 5H). |
- 3
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[ 500770-77-4 ]
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[ 1366063-36-6 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C
2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C |
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- 4
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[ 500770-77-4 ]
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[ 1366063-40-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C
2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C |
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