Home Cart Sign in  
Chemical Structure| 502-44-3 Chemical Structure| 502-44-3
Chemical Structure| 502-44-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of ε-Caprolactone

CAS No. :502-44-3
Formula : C6H10O2
M.W : 114.14
SMILES Code : O=C1OCCCCC1
MDL No. :MFCD00003267
InChI Key :PAPBSGBWRJIAAV-UHFFFAOYSA-N
Pubchem ID :10401

Safety of ε-Caprolactone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of ε-Caprolactone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 502-44-3 ]

[ 502-44-3 ] Synthesis Path-Downstream   1~9

  • 3
  • [ 6651-36-1 ]
  • [ 502-44-3 ]
  • [ 694-82-6 ]
  • [ 108-94-1 ]
  • 4
  • [ 502-44-3 ]
  • [ 149-32-6 ]
  • polymer, 4-arm star-shaped, Mw = 6665; monomer(s): DL-threitol; ε-caprolactone [ No CAS ]
  • 5
  • [ 502-44-3 ]
  • [ 149-32-6 ]
  • polymer, 4-arm star-shaped, Mw = 8450; monomer(s): DL-threitol; ε-caprolactone [ No CAS ]
  • 6
  • [ 502-44-3 ]
  • [ 149-32-6 ]
  • polymer, 4-arm star-shaped, Mw = 10166; monomer(s): DL-threitol; ε-caprolactone [ No CAS ]
  • 8
  • [ 4224-62-8 ]
  • [ 502-44-3 ]
YieldReaction ConditionsOperation in experiment
95 parts by weight of the <strong>[4224-62-8]6-chlorocaproic acid</strong> were boiled with an aqueous solution of the equivalent amount of sodium hydroxide to obtain 69 parts by weight of epsilon-caprolactone. The 13C-NMR (100 MHz, internal standard CDCl3)of the synthesised epsilon-caprolactone was measured to obtain chemical shfts delta (ppm) as follows: epsilon-caprolactone: 13C-NMR (100 MHz, CDCl3) delta (ppm): 176.23, 69.30, 34.56, 29.35, 28.93, 22.98
  • 9
  • [ 502-44-3 ]
  • [ 4102-60-7 ]
  • (15Z,18Z)-6-[(9Z,12Z)-octadeca-9,12-dien-1-yl]tetracosa-15,18-diene-1,6-diol [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% Reaction 1 HGT5000 [0151] The intermediate compound (15Z, 18Z)-6-[ (9Z, 12Z)-octadeca-9, 12-dien-l- yl]tetracosa-15, 18-diene-l, 6-diol identified as compound (2) in Reaction 1 above was prepared as follows. To a lOOmL round bottom flask was added lOg (30mmol) of compound (1) (<strong>[4102-60-7]linoleyl bromide</strong>) and dry THF (20mL) under nitrogen. Magnesium powder (1.1 lg, 45mmol) was added to the stirred reaction solution followed by 2 drops of dibromoethane at room temperature. The reaction mixture was stirred at 50 C for 1 hour, and then diluted with dry THF (40mL). The reaction mixture was stirred another 15 minutes at room temperature. [0152] In a separate 250mL 3-neck flask was taken epsilon-caprolactone (1.44mL, 13.5mmol) in dry THF (20mL) under nitrogen. To the stirred solution was added the Grignard reagent through a cannula at 0 C. The resulting mixture was heated at 85 C for 3 hours. After cooling to room temperature, the reaction mixture was then quenched with NH4CI solution and extracted with dichloromethane (3 x lOOmL). The combined extracts were washed with brine (50mL), dried ( a2S04) and concentrated. The residue was purified twice by silica gel column chromatography (gradient elution from hexane to 3 :2 hexane/EA) to afford compound (2) as an oil. Yield: 5.46g (65%). XH NMR (301 MHz, CDC13) delta: 5.25 - 5.45 (m, 8H), 3.65 (m, 2H), 2.77 (t, J= 6.2 Hz, 4H), 1.95 - 2.1 (m, 8H), 1.2 - 1.70 (m, 50H), 0.88 (t, J= 6.9 Hz, 6H).
 

Historical Records

Technical Information

Categories