Alternatived Products of [ 502649-27-6 ]
Product Details of [ 502649-27-6 ]
CAS No. : | 502649-27-6 |
MDL No. : | MFCD08273956 |
Formula : |
C12H24N2O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
228.33
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 502649-27-6 ]
Application In Synthesis of [ 502649-27-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 502649-27-6 ]
Yield | Reaction Conditions | Operation in experiment |
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208.1 Tert-Butyl 4-(6-ethylthiopheno[3,2-e]pyrimidin-4-yl)-3-propylpiperazinecarboxylate
Step 1: 1-BOC-(d,1)-3-Propylpiperazine was prepared from (d,1)-norvaline according to Example 205. |
- 2
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[ 502649-27-6 ]
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1-((4-bromophenyl)sulfonyl)-2-propylpiperazine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 1 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C |
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- 3
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[ 502649-27-6 ]
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1-(4-((4-bromophenyl)sulfonyl)-3-propylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 1 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: triethylamine / dichloromethane / 2 h / 20 °C |
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- 4
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[ 502649-27-6 ]
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1-(4-((4-(benzylthio)phenyl)sulfonyl)-3-propylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 1 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: triethylamine / dichloromethane / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere |
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- 5
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[ 502649-27-6 ]
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4-((2-propyl-4-(2,2,2-trifluoroacetyl)piperazin-1-yl)sulfonyl)benzenesulfonyl chloride
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 5 steps
1: pyridine / dichloromethane / 1 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: triethylamine / dichloromethane / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
5: N-chloro-succinimide; glacial acetic acid / lithium hydroxide monohydrate / 2 h / 20 °C |
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- 6
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[ 502649-27-6 ]
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N-(3,4-dichloro-1H-indol-7-yl)-4-((2-propyl-4-(2,2,2-trifluoroacetyl)piperazin-1-yl)sulfonyl)benzenesulfonamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 6 steps
1: pyridine / dichloromethane / 1 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: triethylamine / dichloromethane / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
5: N-chloro-succinimide; glacial acetic acid / lithium hydroxide monohydrate / 2 h / 20 °C
6: pyridine / tetrahydrofuran / 4 h / 20 °C |
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- 7
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[ 502649-27-6 ]
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N-(3,4-dichloro-1H-indol-7-yl)-4-((2-propylpiperazin-1-yl)sulfonyl)benzenesulfonamide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 7 steps
1: pyridine / dichloromethane / 1 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3: triethylamine / dichloromethane / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
5: N-chloro-succinimide; glacial acetic acid / lithium hydroxide monohydrate / 2 h / 20 °C
6: pyridine / tetrahydrofuran / 4 h / 20 °C
7: lithium hydroxide monohydrate; potassium carbonate / tetrahydrofuran / 50 °C |
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- 8
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[ 502649-27-6 ]
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[ 98-58-8 ]
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tert-butyl 4-((4-bromophenyl)sulfonyl)-3-propylpiperazine-1-carboxylate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
91.7% |
With pyridine In dichloromethane at 20℃; for 1h; |
17.1 1. Preparation of /er/-butyl 4-((4-bromophenyl)sulfonyl)-3-propylpiperazine-l-carboxylate
To a solution of terZ-butyl 3 -propylpiperazine- 1 -carboxylate (200 mg, 0.88 mmol) in DCM (5 mL) were added pyridine (208.6 mg, 2.64 mmol) and 4- bromobenzenesulfonyl chloride (224.4 mg, 0.88 mmol). The reaction mixture was stirred for 1 h at rt. The reaction mixture was diluted with water (20 mL) and extracted with EA (50 mL x 2). The organic layer was washed with water (20 mL), brine (20 mL), dried over Na2SO4 and concentrated under reduced pressure to afford the crude product, which was purified by column chromatography on silica gel eluted with PE/EA(10/l to 2/1) to give /er/-butyl 4-((4- bromophenyl)sulfonyl)-3 -propylpiperazine- 1 -carboxylate (280.0 mg, 91.7%) as a white solid. LCMS (ESI) found: 347 [M+H]+. |