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[ CAS No. 502649-27-6 ] {[proInfo.proName]}

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Chemical Structure| 502649-27-6
Chemical Structure| 502649-27-6
Structure of 502649-27-6 * Storage: {[proInfo.prStorage]}
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Product Details of [ 502649-27-6 ]

CAS No. :502649-27-6 MDL No. :MFCD08273956
Formula : C12H24N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 228.33 Pubchem ID :-
Synonyms :

Safety of [ 502649-27-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 502649-27-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 502649-27-6 ]

[ 502649-27-6 ] Synthesis Path-Downstream   1~8

YieldReaction ConditionsOperation in experiment
208.1 Tert-Butyl 4-(6-ethylthiopheno[3,2-e]pyrimidin-4-yl)-3-propylpiperazinecarboxylate Step 1: 1-BOC-(d,1)-3-Propylpiperazine was prepared from (d,1)-norvaline according to Example 205.
  • 2
  • [ 502649-27-6 ]
  • 1-((4-bromophenyl)sulfonyl)-2-propylpiperazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 1 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
  • 3
  • [ 502649-27-6 ]
  • 1-(4-((4-bromophenyl)sulfonyl)-3-propylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: pyridine / dichloromethane / 1 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: triethylamine / dichloromethane / 2 h / 20 °C
  • 4
  • [ 502649-27-6 ]
  • 1-(4-((4-(benzylthio)phenyl)sulfonyl)-3-propylpiperazin-1-yl)-2,2,2-trifluoroethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: pyridine / dichloromethane / 1 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: triethylamine / dichloromethane / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
  • 5
  • [ 502649-27-6 ]
  • 4-((2-propyl-4-(2,2,2-trifluoroacetyl)piperazin-1-yl)sulfonyl)benzenesulfonyl chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: pyridine / dichloromethane / 1 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: triethylamine / dichloromethane / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 5: N-chloro-succinimide; glacial acetic acid / lithium hydroxide monohydrate / 2 h / 20 °C
  • 6
  • [ 502649-27-6 ]
  • N-(3,4-dichloro-1H-indol-7-yl)-4-((2-propyl-4-(2,2,2-trifluoroacetyl)piperazin-1-yl)sulfonyl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1: pyridine / dichloromethane / 1 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: triethylamine / dichloromethane / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 5: N-chloro-succinimide; glacial acetic acid / lithium hydroxide monohydrate / 2 h / 20 °C 6: pyridine / tetrahydrofuran / 4 h / 20 °C
  • 7
  • [ 502649-27-6 ]
  • N-(3,4-dichloro-1H-indol-7-yl)-4-((2-propylpiperazin-1-yl)sulfonyl)benzenesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 7 steps 1: pyridine / dichloromethane / 1 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C 3: triethylamine / dichloromethane / 2 h / 20 °C 4: N-ethyl-N,N-diisopropylamine; tris(1,5-diphenylpenta-1,4-dien-3-one)dipalladium; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere 5: N-chloro-succinimide; glacial acetic acid / lithium hydroxide monohydrate / 2 h / 20 °C 6: pyridine / tetrahydrofuran / 4 h / 20 °C 7: lithium hydroxide monohydrate; potassium carbonate / tetrahydrofuran / 50 °C
  • 8
  • [ 502649-27-6 ]
  • [ 98-58-8 ]
  • tert-butyl 4-((4-bromophenyl)sulfonyl)-3-propylpiperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
91.7% With pyridine In dichloromethane at 20℃; for 1h; 17.1 1. Preparation of /er/-butyl 4-((4-bromophenyl)sulfonyl)-3-propylpiperazine-l-carboxylate To a solution of terZ-butyl 3 -propylpiperazine- 1 -carboxylate (200 mg, 0.88 mmol) in DCM (5 mL) were added pyridine (208.6 mg, 2.64 mmol) and 4- bromobenzenesulfonyl chloride (224.4 mg, 0.88 mmol). The reaction mixture was stirred for 1 h at rt. The reaction mixture was diluted with water (20 mL) and extracted with EA (50 mL x 2). The organic layer was washed with water (20 mL), brine (20 mL), dried over Na2SO4 and concentrated under reduced pressure to afford the crude product, which was purified by column chromatography on silica gel eluted with PE/EA(10/l to 2/1) to give /er/-butyl 4-((4- bromophenyl)sulfonyl)-3 -propylpiperazine- 1 -carboxylate (280.0 mg, 91.7%) as a white solid. LCMS (ESI) found: 347 [M+H]+.
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