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Chemical Structure| 50551-88-7 Chemical Structure| 50551-88-7

Structure of 50551-88-7

Chemical Structure| 50551-88-7

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Product Details of [ 50551-88-7 ]

CAS No. :50551-88-7
Formula : C7H14O
M.W : 114.19
SMILES Code : CC(O)CCC(C)=C
MDL No. :MFCD00046665

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Application In Synthesis of [ 50551-88-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50551-88-7 ]

[ 50551-88-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50551-88-7 ]
  • [ 31680-08-7 ]
  • (2S,7S)-2-(p-methoxy-m-nitrophenyl)-4,7-dimethyl-2,3,6,7-tetrahydrooxepine [ No CAS ]
YieldReaction ConditionsOperation in experiment
48% With trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; at -78 - 0℃; for 1h;Molecular sieve; Inert atmosphere; General procedure: To a 10-mL round-bottomed flask with a stir bar and activated molecular sieves, under argon, was added THF (0.2 M) and aldehyde (1.2equiv). The flask was cooled to 0 C for 10 min, after which TMSOTf (1.0 or 1.2 equiv) was added dropwise. After stirring for 5 min, achilled solution (-78 C) of 6-methylhept-6-en-2-ol (5a) or 5-methylhex-5-en-2-ol (34) (50 mg, 1.0 equiv) in THF (0.2 M) was added dropwise over 5 min. The reaction was monitored by TLC (EtOAc-hexanes,5:95) until completion. The reaction was then quenched with sat. NaHCO3 and the mixture was extracted with EtOAc (3 ×). Then, Na2SO4 was added to the combined organic layers, which were then filtered, concentrated, and purified by column chromatography (EtOAc-hexanes, 5:95) to yield the cyclic ether products.
 

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