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Chemical Structure| 510771-81-0 Chemical Structure| 510771-81-0

Structure of 510771-81-0

Chemical Structure| 510771-81-0

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Product Details of [ 510771-81-0 ]

CAS No. :510771-81-0
Formula : C10H8F3N3O
M.W : 243.19
SMILES Code : NCC1=CC=C(C2=NOC(C(F)(F)F)=N2)C=C1
MDL No. :MFCD31690811

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Application In Synthesis of [ 510771-81-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 510771-81-0 ]

[ 510771-81-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 510771-81-0 ]
  • [ 483324-01-2 ]
  • [ 1433205-40-3 ]
YieldReaction ConditionsOperation in experiment
17.95% With N,N-dimethyl acetamide; triethylamine; at 160℃; for 0.166667h;Microwave irradiation; 4-(Pyridin-3-yl)-A -(4-(5-(trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)benzyl)pyrimidin-2- amine, trifluroacetic acid salt: To a suspension of 4-(5-(trifluoromethyl)-1 ,2,4-oxadiazol- 3-yl)phenyl)methanamine (70 mg, 0.29 mmol), <strong>[483324-01-2]2-chloro-4-(pyridin-3-yl)pyrimidine</strong> (50 mg, 0.26 mmol) in A/JV-dimethylacetamide (2.5 ml.) was added a solution of Et3N (0.091 ml_, 0.652 mmol) in one charge. The reaction vessel was sealed and heated to 160 C under microwave irradiation for 10 min. After cooling the reaction, the solvent was removed under reduced pressure, and the mixture was dissolved in MeOH and purified via reverse phase prep-HPLC (10% - 100% MeCN in water with TFA 0.05%) to give a solid. The solid obtained was triturated with Et20 to provide the title compound (24 mg, 0.047 mmol, 17.95 % yield) as a white powder. 1H NMR (400 MHz, METHANOL-^) delta ppm 9.31 (br. s., 1 H), 8.76 (d, J = 5.1 Hz, 2 H), 8.45 (d, J = 5.3 Hz, 1 H), 8.09 (d, J = 8.2 Hz, 2 H), 7.74 - 7.89 (m, 1 H), 7.62 (d, J = 8.0 Hz, 2 H), 7.30 (d, J = 5.3 Hz, 1 H), 4.80 (s, 2 H). LCMS: tR, = 0.82 min, 98%. MS m/z = 399 (M+H)+.
  • 2
  • [ 66389-80-8 ]
  • [ 510771-81-0 ]
 

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