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Chemical Structure| 511268-37-4 Chemical Structure| 511268-37-4

Structure of 511268-37-4

Chemical Structure| 511268-37-4

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Product Details of [ 511268-37-4 ]

CAS No. :511268-37-4
Formula : C6H14ClNO
M.W : 151.63
SMILES Code : O[C@@H]1CNCC1(C)C.[H]Cl

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Application In Synthesis of [ 511268-37-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 511268-37-4 ]

[ 511268-37-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 105806-13-1 ]
  • [ 511268-37-4 ]
  • [ 1152110-73-0 ]
YieldReaction ConditionsOperation in experiment
67% Part A: (3S)-1-(5-Fluoro-6-hydrazino-2-methyl-4-pyrimidinyl)-4,4-dimethyl-3-pyrrolidinol. To a solution of (3S)-4,4-dimethyl-3-pyrrolidinol hydrochloride (Example 115) (0.1370 g, 0.916 mmol) in MeOH (3 mL) was added <strong>[105806-13-1]4,6-dichloro-5-fluoro-2-methylpyrimidine</strong>(0.1646 g, 0.909 mmol) and N,N-diisopropylethylamine (0.350 mL, 2.009 mmol). The solution was heated at 120 0C under microwave irradiation for 30 min, and then concentrated in vacuo. To a solution of the residue in DMSO (3 mL) was added hydrazine hydrate (0.5 mL), and the solution was heated at 50 0C and stirred for 24 h. The solution was then purified directly by Gilson RPLC to provide (3S)-1-(5-fluoro-6- hydrazino-2-methyl-4-pyrimidinyl)-4,4-dimethyl-3-pyrrolidinol (0.1560 g, 67% yield) as a light yellow foam. LCMS: (M+H)+: 256.2.
 

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