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Chemical Structure| 51166-13-3 Chemical Structure| 51166-13-3

Structure of 51166-13-3

Chemical Structure| 51166-13-3

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Product Details of [ 51166-13-3 ]

CAS No. :51166-13-3
Formula : C16H18O
M.W : 226.31
SMILES Code : OC(C1=CC=CC=C1)C2=CC=C(CCC)C=C2
MDL No. :MFCD11100904

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Application In Synthesis of [ 51166-13-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51166-13-3 ]

[ 51166-13-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 28785-06-0 ]
  • [ 591-51-5 ]
  • [ 51166-13-3 ]
YieldReaction ConditionsOperation in experiment
46% In tetrahydrofuran; at 0 - 20℃; for 4h;Inert atmosphere; 4-Propylbenzaldehyde (398 muL, 2.70 mmol) was dissolved in THF under an argon atmosphere. Phenyllithium (7.1 mL of a 1.9 M solution in THF, 13.5 mmol) was added under stirring at 0 °C. The reaction mixture was allowed to reach ambient temperature, and was then stirred for 4 h. The reaction was quenched by addition of water (20 mL). The mixture was extracted with EtOAc (2.x.20 mL). The combined organic phases were washed with brine, dried over MgSO4 and concentrated. The crude product was purified by flash column chromatography (pentane/ethyl acetate 8:1), to give 1c (280 mg, 46percent) as a colourless oil. 1H NMR: 0.94 (t, 3H, J=7.3), 1.58-1.68 (m, 2H), 2.57 (t, 2H, J=7.7), 5.84 (d, 1H, J=3.5), 7.13-7.18 (m, 2H), 7.25-7.40 (m, 7H). 13C NMR: 13.8, 24.5, 37.7, 76.1, 126.5, 126.5, 127.4, 128.4, 128.6, 141.2, 142.1, 143.9. IR (liquid film, cm-1): 3500-3050 (br), 2958, 2929, 1453, 1175, 1015. MS(ESI-TOF): calcd for [M+Na]+: 249.1250; Found: 249.1248.
 

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