Alternatived Products of [ 51344-12-8 ]
Product Details of [ 51344-12-8 ]
CAS No. : | 51344-12-8 |
MDL No. : | MFCD18800941 |
Formula : |
C11H17NO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | LTVRUDZZRDMXFX-UHFFFAOYSA-N |
M.W : |
195.26
|
Pubchem ID : | 15082317 |
Synonyms : |
|
Application In Synthesis of [ 51344-12-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 51344-12-8 ]
- 1
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[ 22921-76-2 ]
-
[ 124-40-3 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
With ethanol at 120 - 130℃; |
|
- 2
-
[ 51344-12-8 ]
-
[ 75-03-6 ]
-
[ 137325-71-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
In diethyl ether Ambient temperature; |
|
- 3
-
[ 137325-67-8 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
55% |
With lithium aluminium tetrahydride In diethyl ether Ambient temperature; |
|
- 4
-
[ 51344-12-8 ]
-
[ 74-88-4 ]
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[2-(4-Methoxy-phenoxy)-ethyl]-trimethyl-ammonium; iodide
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
In diethyl ether Ambient temperature; |
|
- 5
-
[ 51344-12-8 ]
-
[ 4101-68-2 ]
-
[ 2603-69-2 ]
Yield | Reaction Conditions | Operation in experiment |
|
In butanone Heating; |
|
- 6
-
[ 51344-12-8 ]
-
[ 100238-29-7 ]
Yield | Reaction Conditions | Operation in experiment |
7.26 mmol |
With boron tribromide In dichloromethane at 0℃; for 4h; |
|
Reference:
[1]Hoekstra, William J.; Patel, Hari S.; Liang, Xi; Blanc, Jean-Baptiste E.; Heyer, Dennis O.; Willson, Timothy M.; Iannone, Marie A.; Kadwell, Sue H.; Miller, Lisa A.; Pearce, Kenneth H.; Simmons, Catherine A.; Shearin, Jean
[Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 2243 - 2247]
- 7
-
[ 4584-46-7 ]
-
[ 150-76-5 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; |
|
Reference:
[1]Hoekstra, William J.; Patel, Hari S.; Liang, Xi; Blanc, Jean-Baptiste E.; Heyer, Dennis O.; Willson, Timothy M.; Iannone, Marie A.; Kadwell, Sue H.; Miller, Lisa A.; Pearce, Kenneth H.; Simmons, Catherine A.; Shearin, Jean
[Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 2243 - 2247]
- 8
-
[ 51344-12-8 ]
-
{2-[4-(2-ethyl-7-methoxy-3-phenyl-quinolin-4-yloxy)-phenoxy]-ethyl}-dimethyl-amine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 7.26 mmol / BBr3 / CH2Cl2 / 4 h / 0 °C
2: NaOH / dimethylformamide / 110 °C |
|
Reference:
[1]Hoekstra, William J.; Patel, Hari S.; Liang, Xi; Blanc, Jean-Baptiste E.; Heyer, Dennis O.; Willson, Timothy M.; Iannone, Marie A.; Kadwell, Sue H.; Miller, Lisa A.; Pearce, Kenneth H.; Simmons, Catherine A.; Shearin, Jean
[Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 2243 - 2247]
- 9
-
[ 51344-12-8 ]
-
4-[4-(2-dimethylamino-ethoxy)-phenoxy]-2-ethyl-3-phenyl-quinolin-7-ol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 7.26 mmol / BBr3 / CH2Cl2 / 4 h / 0 °C
2: NaOH / dimethylformamide / 110 °C
3: 0.0148 g / BBr3 / CH2Cl2 / 4 h / -20 - 20 °C |
|
Reference:
[1]Hoekstra, William J.; Patel, Hari S.; Liang, Xi; Blanc, Jean-Baptiste E.; Heyer, Dennis O.; Willson, Timothy M.; Iannone, Marie A.; Kadwell, Sue H.; Miller, Lisa A.; Pearce, Kenneth H.; Simmons, Catherine A.; Shearin, Jean
[Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 2243 - 2247]
- 10
-
[ 1877-75-4 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1: 4.2 g / SOCl2 / Ambient temperature
2: 80 percent / benzene; H2O / Ambient temperature
3: 55 percent / LiAlH4 / diethyl ether / Ambient temperature |
|
- 11
-
[ 42082-29-1 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: 80 percent / benzene; H2O / Ambient temperature
2: 55 percent / LiAlH4 / diethyl ether / Ambient temperature |
|
- 12
-
[ 150-76-5 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: 39 percent / 6N NaOH / H2O / 2 h / Heating
2: 4.2 g / SOCl2 / Ambient temperature
3: 80 percent / benzene; H2O / Ambient temperature
4: 55 percent / LiAlH4 / diethyl ether / Ambient temperature |
|
- 13
-
[ 108-01-0 ]
-
[ 150-76-5 ]
-
[ 105-58-8 ]
-
[ 5076-72-2 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
With potassium carbonate In acetonitrile at 200℃; for 8h; Autoclave; |
|
Reference:
[1]Annatelli, Mattia; Trapasso, Giacomo; Salaris, Claudio; Salata, Cristiano; Castellano, Sabrina; Aricò, Fabio
[European Journal of Organic Chemistry, 2021, vol. 2021, # 24, p. 3459 - 3464]
- 14
-
[ 20570-41-6 ]
-
[ 150-76-5 ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
96% |
In acetonitrile at 220℃; for 0.116667h; Sealed tube; Microwave irradiation; |
Reaction between 2-(dimethylamino)ethyl methyl carbonate 2 and phenol in ACN - Table 1, No.7
General procedure: Phenol (0.060 g, 0.637 mmol) was dissolved in ACN (3 mL) at room temperature in a 10 mL CEM pressure vessel equipped with a stirrer bar. 2-(Dimethylamino)ethyl methyl carbonate 2 (0.140 g, 0.955 mmol) was added and the vial was sealed and heated in a CEM Discover microwave synthesizer to 220 °C for 7 min. After cooling, a sample of the crude material was analysed by HPLC to define conversion and selectivity. Then, the reaction mixture was concentrated via rotavapor and it was purified via liquid-liquid extraction (EtOAc 50 mL / NaOH 5% aqueous solution 50 mL x 3). The organic phase was dried with sodium sulphate, filtered and concentrated under vacuum. The pure compound was isolated as a brown oil in 95% yield (0.100 g). Characterization of compound 3 was consistent with one reported in the literature.2 |
Reference:
[1]Viviano, Monica; Trapasso, Giacomo; Annatelli, Mattia; Milite, Ciro; Castellano, Sabrina; Aricò, Fabio
[Synthesis, 2022, vol. 54, # 11, p. 2595 - 2603]
- 15
-
[ 20570-41-6 ]
-
[ 150-76-5 ]
-
[ 67-63-0 ]
-
2-(dimethylamino)ethyl isopropyl carbonate
[ No CAS ]
-
[ 51344-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
|
at 220℃; for 0.116667h; Sealed tube; Microwave irradiation; |
|
Reference:
[1]Viviano, Monica; Trapasso, Giacomo; Annatelli, Mattia; Milite, Ciro; Castellano, Sabrina; Aricò, Fabio
[Synthesis, 2022, vol. 54, # 11, p. 2595 - 2603]
- 16
-
[ 20570-41-6 ]
-
[ 150-76-5 ]
-
[ 71-36-3 ]
-
[ 51344-12-8 ]
-
butyl (2-(dimethylamino)ethyl) carbonate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
at 220℃; for 0.116667h; Sealed tube; Microwave irradiation; |
|
Reference:
[1]Viviano, Monica; Trapasso, Giacomo; Annatelli, Mattia; Milite, Ciro; Castellano, Sabrina; Aricò, Fabio
[Synthesis, 2022, vol. 54, # 11, p. 2595 - 2603]