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[ CAS No. 5142-23-4 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 5142-23-4
Chemical Structure| 5142-23-4
Structure of 5142-23-4 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 5142-23-4 ]

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Alternatived Products of [ 5142-23-4 ]

Product Details of [ 5142-23-4 ]

CAS No. :5142-23-4 MDL No. :MFCD00010531
Formula : C6H7N5 Boiling Point : -
Linear Structure Formula :- InChI Key :ZPBYVFQJHWLTFB-UHFFFAOYSA-N
M.W : 149.15 Pubchem ID :135398661
Synonyms :
3-MA;NSC 66389;3-Methyladenine, NSC 66389

Calculated chemistry of [ 5142-23-4 ]

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.17
Num. rotatable bonds : 0
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 40.99
TPSA : 69.62 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -7.62 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.17
Log Po/w (XLOGP3) : -0.58
Log Po/w (WLOGP) : -0.05
Log Po/w (MLOGP) : -0.44
Log Po/w (SILICOS-IT) : -0.23
Consensus Log Po/w : -0.03

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.0
Solubility : 14.8 mg/ml ; 0.0989 mol/l
Class : Very soluble
Log S (Ali) : -0.41
Solubility : 57.8 mg/ml ; 0.388 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.35
Solubility : 6.66 mg/ml ; 0.0447 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.69

Safety of [ 5142-23-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 5142-23-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5142-23-4 ]

[ 5142-23-4 ] Synthesis Path-Downstream   1~79

  • 1
  • [ 98135-51-4 ]
  • [ 5142-23-4 ]
  • 2
  • [ 77-78-1 ]
  • [ 58-61-7 ]
  • [ 5142-22-3 ]
  • [ 5142-23-4 ]
  • 3
  • [ 5142-23-4 ]
  • [ 100-39-0 ]
  • [ 107293-00-5 ]
  • [ 107293-01-6 ]
  • 4
  • [ 5142-23-4 ]
  • [ 75-03-6 ]
  • [ 107292-99-9 ]
  • 5
  • [ 5142-23-4 ]
  • [ 74-88-4 ]
  • [ 89885-39-2 ]
  • 6
  • [ 5142-23-4 ]
  • [ 1006-11-7 ]
  • 7
  • [ 5142-23-4 ]
  • [ 1006-11-7 ]
  • [ 90801-87-9 ]
  • 9
  • [ 125661-70-3 ]
  • [ 5142-23-4 ]
  • [ 125661-58-7 ]
  • 10
  • [ 73-24-5 ]
  • [ 74-88-4 ]
  • [ 5142-23-4 ]
  • [ 935-69-3 ]
  • [ 700-00-5 ]
  • 11
  • [ 76227-27-5 ]
  • [ 5142-23-4 ]
  • 13
  • [ 76227-26-4 ]
  • [ 5142-23-4 ]
  • 5-(Formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine [ No CAS ]
  • 15
  • 7-methoxy-3-methyladenine perchlorate salt [ No CAS ]
  • [ 5142-23-4 ]
  • 17
  • [ 5142-23-4 ]
  • (1R,2S,4aR,8aS)-1-((E)-5-Bromo-3-methyl-pent-3-enyl)-1,2,5,5-tetramethyl-octahydro-naphthalen-4a-ol [ No CAS ]
  • (+/-)-<1α(E),2β,4aβ,8aα>-1-<5-(3,6-dihydro-6-imino-3-methyl-7H-purin-7-yl)-3-methyl-3-pentenyl>octahydro-1,2,5,5-tetramethyl-4a(2H)-naphthalenol [ No CAS ]
  • 19
  • [ 5142-23-4 ]
  • C6H4(2)H3N5 [ No CAS ]
  • 20
  • [ 5142-23-4 ]
  • [ 58-97-9 ]
  • uridine 5'-phosphoro-3-methyladeninium [ No CAS ]
  • 21
  • [ 5142-23-4 ]
  • [ 61-19-8 ]
  • adenosine 5'-phosphoro-3-methyladeninium [ No CAS ]
  • 24
  • [ 5142-23-4 ]
  • [ 50848-64-1 ]
  • [ 943232-30-2 ]
  • 25
  • [ 5142-23-4 ]
  • [ 100-39-0 ]
  • 7-benzyl-3-methyladenine [ No CAS ]
  • 28
  • [ 5142-23-4 ]
  • [ 185201-07-4 ]
  • 29
  • [ 5142-23-4 ]
  • [ 185201-08-5 ]
  • 30
  • [ 5142-23-4 ]
  • 7-methoxy-3-methyladenine [ No CAS ]
  • 32
  • [ 5142-23-4 ]
  • 7-Ethoxy-3-methyl-3,7-dihydro-purin-6-ylideneamine [ No CAS ]
  • 33
  • [ 5142-23-4 ]
  • 7-Benzyloxy-3-methyl-3,7-dihydro-purin-6-ylideneamine [ No CAS ]
  • 34
  • [ 5142-23-4 ]
  • (1R,2S,4aR,8aS)-1-[(E)-5-(6-Imino-3-methyl-1,2,3,6-tetrahydro-purin-7-yl)-3-methyl-pent-3-enyl]-1,2,5,5-tetramethyl-octahydro-naphthalen-4a-ol [ No CAS ]
  • 36
  • [ 5142-23-4 ]
  • (+/-)-agelasimine-B [ No CAS ]
  • 37
  • [ 5142-23-4 ]
  • 7-[(E)-5-((1R,2S,4aR,8aS)-4a-Hydroxy-1,2,5,5-tetramethyl-decahydro-naphthalen-1-yl)-3-methyl-pent-2-enyl]-2,3-dimethyl-3,7-dihydro-purin-6-one [ No CAS ]
  • 38
  • [ 5142-23-4 ]
  • 7-[(E)-5-((1R,2S,4aR,8aS)-4a-Hydroxy-1,2,5,5-tetramethyl-decahydro-naphthalen-1-yl)-3-methyl-pent-2-enyl]-1,3-dimethyl-1,2,3,7-tetrahydro-purin-6-one [ No CAS ]
  • 39
  • [ 5142-23-4 ]
  • N6-acetylagelsimine-B [ No CAS ]
  • 40
  • [ 5142-23-4 ]
  • N-([(Z)-Acetylimino]-{5-(formyl-methyl-amino)-3-[(E)-5-((1R,2S,4aR,8aS)-4a-hydroxy-1,2,5,5-tetramethyl-decahydro-naphthalen-1-yl)-3-methyl-pent-2-enyl]-3H-imidazol-4-yl}-methyl)-N-methyl-acetamide [ No CAS ]
  • 41
  • [ 5142-23-4 ]
  • 5-(Formyl-methyl-amino)-3-[(E)-5-((1R,2S,4aR,8aS)-4a-hydroxy-1,2,5,5-tetramethyl-decahydro-naphthalen-1-yl)-3-methyl-pent-2-enyl]-N-methyl-3H-imidazole-4-carboxamidine [ No CAS ]
  • 42
  • [ 21149-25-7 ]
  • [ 5142-23-4 ]
  • 43
  • [ 66224-66-6 ]
  • [ 5142-23-4 ]
  • 44
  • [ 7280-81-1 ]
  • [ 5142-23-4 ]
  • 45
  • [ 155854-86-7 ]
  • [ 5142-23-4 ]
  • 53
  • [ 72055-59-5 ]
  • [ 5142-23-4 ]
  • 54
  • [ 72055-61-9 ]
  • [ 5142-23-4 ]
  • 55
  • [ 50507-48-7 ]
  • [ 5142-23-4 ]
  • 56
  • [ 5142-23-4 ]
  • [ 115377-66-7 ]
  • 57
  • [ 125661-65-6 ]
  • [ 5142-23-4 ]
  • 58
  • [ 5142-23-4 ]
  • [ 74-88-4 ]
  • [ 51584-34-0 ]
  • 59
  • acetylacetonatodicarbonylrhodium(l) [ No CAS ]
  • [ 5142-23-4 ]
  • [ 67-68-5 ]
  • [ 132872-94-7 ]
  • 60
  • [ 5142-23-4 ]
  • methylmercury(II) hydroxide [ No CAS ]
  • 3-methyladenine (methylmercury)3(NO3) [ No CAS ]
  • 61
  • [ 5142-23-4 ]
  • methylmercury(II) hydroxide [ No CAS ]
  • 3-methyladenine (methylmercury)3(NO3)2*H2O [ No CAS ]
  • 62
  • [ 5142-23-4 ]
  • methylmercury(II) hydroxide [ No CAS ]
  • 3-methyladenine methylmercury (NO3) [ No CAS ]
  • 63
  • [ 5142-23-4 ]
  • methylmercury(II) hydroxide [ No CAS ]
  • 3-methyladenine (methylmercury)2(NO3)2 [ No CAS ]
  • 64
  • [ 5142-23-4 ]
  • methylmercury(II) hydroxide [ No CAS ]
  • 3-methyladenine (methylmercury)2NO3*H2O [ No CAS ]
  • 65
  • [ 5142-23-4 ]
  • [ 714956-88-4 ]
  • [ 1006607-26-6 ]
  • 66
  • [ 5142-23-4 ]
  • dipotassium[copper(II)(oxalate)2] monoxydrate [ No CAS ]
  • [ 7732-18-5 ]
  • [ 6487-48-5 ]
  • [copper(II)(μ-oxalate)(3-methyladenine)(H2O)] monohydrate [ No CAS ]
  • 67
  • [ 66224-66-6 ]
  • [ 74-88-4 ]
  • [ 5142-23-4 ]
  • [ 700-00-5 ]
  • 68
  • methylated genomic DNA [ No CAS ]
  • [ 5142-23-4 ]
  • 69
  • [ 5142-23-4 ]
  • [ 7732-18-5 ]
  • [ 6487-48-5 ]
  • potassium bis(oxalato)cuprate(II) dihydrate [ No CAS ]
  • [Cu(μ-oxalato)(3-methyladenine)2](H2O)}n [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; at 50℃; An aqueous-methanol solution (10 mL, 1/1 ratio) of <strong>[5142-23-4]3-methyladenine</strong>(0.020 g, 0.14 mmol) was added dropwise to an aqueousmixture (10 mL) of K2[Cu(ox)2]2H2O (0.050 g, 0.14 mmol) andK2(ox)H2O (0.026 g, 0.14 mmol) with continuous stirring at50 C. The resulting solution was allowed to evaporate at roomtemperature. Green single crystals of 6 were obtained after four days. Yield: 30-35%. Found: C, 32.11; H, 4.17; N, 26.69; Cu,12.10. C14H22CuN10O8 requires C, 32.22.; H, 4.25; N, 26.84; Cu,12.18%. FT-IR numax(KBr pellet)/cm1: 3430sh, for m(OAH); 3380s,3327s, for (m(NH2) + 2d(NH2)); 3158sh, for (m(C8-H + C2-H) +(m(NH2)); 3117s, 3065sh, for (m(CH3)); 1668vs, 1623vs, for(mas (OACAO)); 1592vs, for (m(CC) + (dNH2)); 1520m, for(m(C4-C5) + N3-C4-C5)); 1464m, 1444w, for (d(C2-H + C8-N9) + m(C8-H)); 1416s, for d(N1-C6-H6); 1380w, 1358w, for m(C5-N7-C8) +(d(CH3)); 1327w, 1304m, 1273w, 1249w, for (m(N9-C8 + N3-C2)+ d(CAH) + ms(OACAO)); 1200s, for (d(C8-H) + m(N7-C8)); 1050w,1031w, for s(NH2); 1008w, 928w, for (m(N1-C6) + s(NH2)); 797m,for d(OACAO); 626m, 608m, for ring deformation; 581 m; 542sh;492w, for m(M-O+M-N).
  • 70
  • [ 5142-23-4 ]
  • [ 7732-18-5 ]
  • [ 6487-48-5 ]
  • [ 14646-43-6 ]
  • [Co(μ-oxalato)(H2O)(3-methyladenine)]*H2O}n [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; at 50℃; General procedure: An aqueous mixture of [Zn(mu-ox)(H2O)2]n (0.026 g, 0.14 mmol)and K2(ox)H2O (0.505 g, 2.74 mmol) was added dropwise to anaqueous-methanol solution (20 mL, 1/1 ratio) of <strong>[5142-23-4]3-methyladenine</strong>(0.010 g, 0.07 mmol) at 50 C. The resulting solution was left toevaporate. Not very well shaped colourless crystals of 3 wereobtained after one month. Yield: 20-25%.
  • 71
  • [ 5142-23-4 ]
  • [ 7732-18-5 ]
  • [ 6487-48-5 ]
  • [ 89087-78-5 ]
  • [Mn(μ-oxalato)(H2O)(3-methyladenine)]*(H2O)}n [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; at 50℃; An aqueous-methanol solution (10 mL, 1/1 ratio) of <strong>[5142-23-4]3-methyladenine</strong>(0.020 g, 0.14 mmol) was added dropwise to an aqueousmixture (15 mL) of [Mn(mu-ox)(H2O)2]n (0.025 g, 0.14 mmol) andK2(ox)H2O (0.151 g, 0.82 mmol) with continuous stirring at 50 C.The resulting solution was allowed to evaporate. Colourless singlecrystals of 5 were grown after four days. Yield: 45-50%. Found:C, 29.37; H, 3.34; N, 21.38; Mn, 16.81. C8H11MnN5O6 requires C,29.28; H, 3.38; N, 21.34; Mn, 16.74%. FT-IR numax(KBr pellet)/cm1:3503s, for m(OAH); 3450s, for (m(NH2) + 2d(NH2)); 3367s, 3320s,for (m(C8-H + C2-H) + (m(NH2)); 3173s, for (m(CH3)); 1678vs, for(mas (OACAO)); 1610vs, 1573sh, for (m(CC) + (dNH2)); 1523m, for(m(C4-C5) + N3-C4-C5)); 1463m, for (d(C2-H + C8-N9) + m(C8-H));1416s, for d(N1-C6-H6); 1338m, 1307m, for m(C5-N7-C8) +(d(CH3)); 1261m, 1243w, for (m(N9-C8 + N3-C2) + d(CAH) +ms(OACAO)); 1208s, for (d(C8-H) + m(N7-C8)); 1047w, 1007m, fors(NH2); 933w, 913w, 882w, for (m(N1-C6) + s(NH2)); 794s, ford(OACAO); 673m, 652m, 621w, for ring deformation; 582w;539w; 510w, 469w, for m(M-O+M-N).
  • 72
  • [ 5142-23-4 ]
  • [ 7732-18-5 ]
  • [ 6487-48-5 ]
  • [ 16788-40-2 ]
  • [Zn(μ-oxalato)(H2O)(3-methyladenine)]*H2O}n [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; at 50℃; An aqueous mixture of [Zn(mu-ox)(H2O)2]n (0.026 g, 0.14 mmol)and K2(ox)H2O (0.505 g, 2.74 mmol) was added dropwise to anaqueous-methanol solution (20 mL, 1/1 ratio) of <strong>[5142-23-4]3-methyladenine</strong>(0.010 g, 0.07 mmol) at 50 C. The resulting solution was left toevaporate. Not very well shaped colourless crystals of 3 wereobtained after one month. Yield: 20-25%. Found: C, 28.26; H,3.22; N, 20.78; Zn, 19.39. C8H11N5O6Zn requires C, 28.38; H, 3.27;N, 20.68; Zn, 19.31%. FT-IR numax(KBr pellet)/cm1: 3508s, for m(OAH); 3442s, for (m(NH2) + 2d(NH2)); 3364s, 3314s, for (m(C8-H+ C2-H) + (m(NH2)); 3162s, for (m(CH3)); 1682vs, for (mas (OACAO));1612vs, 1575sh, for (m(CC) + (dNH2)); 1525m, for (m(C4-C5) +N3-C4-C5)); 1463m, for (d(C2-H + C8-N9) + m(C8-H)); 1418s, for d(N1-C6-H6); 1342s, 1309s, for m(C5-N7-C8) + (d(CH3)); 1267m,1249sh, 1233w, for (m(N9-C8 + N3-C2) + d(CAH) + ms(OACAO));1209s, for (d(C8-H) + m(N7-C8)); 1051w, 1011m, for s(NH2);936w, 916w, for (m(N1-C6) + s(NH2)); 803s, 783sh, for d(OACAO);671m, 649m, 620w, for ring deformation; 583w; 538 m; 466m,for m(M-O+M-N).
  • 73
  • copper (II) carbonate hydroxide [ No CAS ]
  • [ 5142-23-4 ]
  • [ 1268069-02-8 ]
  • [ 7732-18-5 ]
  • [Cu(N-(p-chlorobenzyl)iminodiacetate)(3-methyladenine)]*H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 15% General procedure: In a Kitasato flask, Cu2CO3(OH)2 (0.25 mmol) was reacted with0.5 mmol of the corresponding iminodiacetic-like acids H2IDA (1,4,11),H2MIDA (5,10,12), H2EIDA (13), H2FurIDA (8), H2NBzIDA (6,14),H2MEBIDA (15), H2CBIDA (2,9,16) and H2NamIDA (3,7) in 60 mL ofdistilled water with heating (50 C), stirring and moderate vacuum.Once a clear blue solution of the binary chelate was obtained, thecorresponding Meade ligand (0.5 mmol) was added: 1Meade (1-3),3Meade (4-9), 7Meade (10), 9Meade (11-16). The solution was leftreacting for one hour. Afterwards, it was filtered in a crystallizationdevice (to remove possible un-reacted materials) and stood at r.t. coveredwith a plastic film to control the evaporation of the solvents.
  • 74
  • copper (II) carbonate hydroxide [ No CAS ]
  • [ 5142-23-4 ]
  • (1-naphthylmethyl)iminodiacetic acid [ No CAS ]
  • [ 7732-18-5 ]
  • [Cu((1-naphthylmethyl)iminodiacetate)(3-methyladenine)(H2O)]*2H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 80% General procedure: In a Kitasato flask, Cu2CO3(OH)2 (0.25 mmol) was reacted with0.5 mmol of the corresponding iminodiacetic-like acids H2IDA (1,4,11),H2MIDA (5,10,12), H2EIDA (13), H2FurIDA (8), H2NBzIDA (6,14),H2MEBIDA (15), H2CBIDA (2,9,16) and H2NamIDA (3,7) in 60 mL ofdistilled water with heating (50 C), stirring and moderate vacuum.Once a clear blue solution of the binary chelate was obtained, thecorresponding Meade ligand (0.5 mmol) was added: 1Meade (1-3),3Meade (4-9), 7Meade (10), 9Meade (11-16). The solution was leftreacting for one hour. Afterwards, it was filtered in a crystallizationdevice (to remove possible un-reacted materials) and stood at r.t. coveredwith a plastic film to control the evaporation of the solvents.
  • 75
  • copper (II) carbonate hydroxide [ No CAS ]
  • [ 5142-23-4 ]
  • [ 7732-18-5 ]
  • [ 142-73-4 ]
  • [Cu(iminodiacetate)(3-methyladenine)(H2O)2]*3H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 63% General procedure: In a Kitasato flask, Cu2CO3(OH)2 (0.25 mmol) was reacted with0.5 mmol of the corresponding iminodiacetic-like acids H2IDA (1,4,11),H2MIDA (5,10,12), H2EIDA (13), H2FurIDA (8), H2NBzIDA (6,14),H2MEBIDA (15), H2CBIDA (2,9,16) and H2NamIDA (3,7) in 60 mL ofdistilled water with heating (50 C), stirring and moderate vacuum.Once a clear blue solution of the binary chelate was obtained, thecorresponding Meade ligand (0.5 mmol) was added: 1Meade (1-3),3Meade (4-9), 7Meade (10), 9Meade (11-16). The solution was leftreacting for one hour. Afterwards, it was filtered in a crystallizationdevice (to remove possible un-reacted materials) and stood at r.t. coveredwith a plastic film to control the evaporation of the solvents.
  • 76
  • copper (II) carbonate hydroxide [ No CAS ]
  • [ 57362-11-5 ]
  • [ 5142-23-4 ]
  • [ 7732-18-5 ]
  • [Cu(N-furfuryliminodiacetate)(3-methyladenine)(H2O)]*4H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 80% General procedure: In a Kitasato flask, Cu2CO3(OH)2 (0.25 mmol) was reacted with0.5 mmol of the corresponding iminodiacetic-like acids H2IDA (1,4,11),H2MIDA (5,10,12), H2EIDA (13), H2FurIDA (8), H2NBzIDA (6,14),H2MEBIDA (15), H2CBIDA (2,9,16) and H2NamIDA (3,7) in 60 mL ofdistilled water with heating (50 C), stirring and moderate vacuum.Once a clear blue solution of the binary chelate was obtained, thecorresponding Meade ligand (0.5 mmol) was added: 1Meade (1-3),3Meade (4-9), 7Meade (10), 9Meade (11-16). The solution was leftreacting for one hour. Afterwards, it was filtered in a crystallizationdevice (to remove possible un-reacted materials) and stood at r.t. coveredwith a plastic film to control the evaporation of the solvents.
  • 77
  • copper (II) carbonate hydroxide [ No CAS ]
  • [ 5142-23-4 ]
  • [ 3987-53-9 ]
  • [ 7732-18-5 ]
  • [Cu(N-benzyliminodiacetate)(3-methyladenine)(H2O)]*2H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 85% General procedure: In a Kitasato flask, Cu2CO3(OH)2 (0.25 mmol) was reacted with0.5 mmol of the corresponding iminodiacetic-like acids H2IDA (1,4,11),H2MIDA (5,10,12), H2EIDA (13), H2FurIDA (8), H2NBzIDA (6,14),H2MEBIDA (15), H2CBIDA (2,9,16) and H2NamIDA (3,7) in 60 mL ofdistilled water with heating (50 C), stirring and moderate vacuum.Once a clear blue solution of the binary chelate was obtained, thecorresponding Meade ligand (0.5 mmol) was added: 1Meade (1-3),3Meade (4-9), 7Meade (10), 9Meade (11-16). The solution was leftreacting for one hour. Afterwards, it was filtered in a crystallizationdevice (to remove possible un-reacted materials) and stood at r.t. coveredwith a plastic film to control the evaporation of the solvents.
  • 78
  • copper (II) carbonate hydroxide [ No CAS ]
  • [ 5142-23-4 ]
  • [ 4408-64-4 ]
  • [ 7732-18-5 ]
  • [Cu(N-methyliminodiacetate)(3-methyladenine)(H2O)]*6H2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
Ca. 85% General procedure: In a Kitasato flask, Cu2CO3(OH)2 (0.25 mmol) was reacted with0.5 mmol of the corresponding iminodiacetic-like acids H2IDA (1,4,11),H2MIDA (5,10,12), H2EIDA (13), H2FurIDA (8), H2NBzIDA (6,14),H2MEBIDA (15), H2CBIDA (2,9,16) and H2NamIDA (3,7) in 60 mL ofdistilled water with heating (50 C), stirring and moderate vacuum.Once a clear blue solution of the binary chelate was obtained, thecorresponding Meade ligand (0.5 mmol) was added: 1Meade (1-3),3Meade (4-9), 7Meade (10), 9Meade (11-16). The solution was leftreacting for one hour. Afterwards, it was filtered in a crystallizationdevice (to remove possible un-reacted materials) and stood at r.t. coveredwith a plastic film to control the evaporation of the solvents.
  • 79
  • thallium(I) hexafluorophosphate [ No CAS ]
  • [ 5142-23-4 ]
  • [ 20555-33-3 ]
  • C42H36N5P2Pt(1+)*F6P(1-) [ No CAS ]
YieldReaction ConditionsOperation in experiment
94% General procedure: A suspension of [Pt(CO3)(PPh3)2]·CH2Cl2 (1) and [Pt(CO3)(dppe)](2), respectively (100 mg) in methanol (10 mL) was reacted with 1.1equivalents of the respective adenine derivative with stirring for 24 h atroom temperature. After addition of 1.1 equivalents of Tl[PF6] the reactionmixture was stirred for further 24 h. Then, the reaction mixturewas filtered over Kieselgur, which was washed with methanol(3 × 5 mL). The volume of the combined methanolic solutions wasreduced in vacuum down to about 0.5 mL. Addition of diethyl etherresulted in precipitation of the product, which was filtered off, washedwith diethyl ether and dried in vacuum.
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