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Chemical Structure| 5205-34-5 Chemical Structure| 5205-34-5

Structure of Decan-5-ol
CAS No.: 5205-34-5

Chemical Structure| 5205-34-5

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Product Details of [ 5205-34-5 ]

CAS No. :5205-34-5
Formula : C10H22O
M.W : 158.28
SMILES Code : CCCCC(O)CCCCC
MDL No. :MFCD00039626

Safety of [ 5205-34-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315
Precautionary Statements:P210-P280-P370+P378-P403+P235-P501

Application In Synthesis of [ 5205-34-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5205-34-5 ]

[ 5205-34-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5205-34-5 ]
  • [ 3543-75-7 ]
  • [ 1609623-11-1 ]
YieldReaction ConditionsOperation in experiment
24.2% With dmap; dicyclohexyl-carbodiimide; In 1,2-dichloro-ethane; at 75℃; for 120h;Inert atmosphere; Preparation of 4-{5-[Bis-(chloroethyl)-amino]-l-methyl-lH-benzimidazol-2-yl}butyric acid 5-decyl ester (branched <strong>[3543-75-7]bendamustine</strong> Cj ester): A 250 mL three neck round bottom flask was equipped with an overhead stirrer, thermocouple, temperature controller and nitrogen sweep then charged with 3.0 g (7.6 mmol) of <strong>[3543-75-7]<strong>[3543-75-7]bendamustine</strong> hydrochloride</strong>, 1.21 g (7.7 mmol, 1.01 eq) of 5-decanol, 1.59 g (7.7 mmol, 1.01 eq) of dicyclohexylcarbodiimide (DCC), 30 mL of 1,2- ethylene dichloride (EDC)and 0.1 g (0.76 mmol, 0.1 eq) of DMAP. The reaction was stirred at 75C for five days until an in process analysis indicated the reaction was complete. Solids were removed by vacuum filtration and washed with 5 mL of EDC. The filtrate was washed with 4% aqueous sodium bicarbonate solution (1 X 50 mL) before drying over sodium sulfate, filtering and concentrating to dryness in vacuo. The residue was combined with the residue from a lOg batch run carried out under the same conditions and the combined batches were chromatographed. The chromatography was carried out using 100 g of silica gel 60, 230-400 mesh, eluting with first 2 L of heptanes, then 1 L of 3 : 1 heptane/EtOAc and 1L of 2: 1 heptane/EtOAc collecting 100 mL fractions. Product containing fractions were combined and concentrated to dryness in vacuo to yield 3.97 g (7.96 mmol, 24.2%) of the product as a clear yellow oil with an HPLC purity of 99.4A%.1H NMR (400 MHz, DMSO-d6) delta 7.31 (d, J = 8.76 Hz, 1H), 6.93 (d, J = 2.28 Hz, 1H), 6.78 (dd, J= 2.40, 8.80 Hz, 1H), 4.8 (m, 1H), 3.7 (s, 8H), 3.65 (s, 3H), 2.83 (t, J= 7.4 Hz, 2H), 2.44 (t, J= 7.36 Hz, 2H), 2.02 (m, 2H), 1.48 (m, 4H), 1.25 (s, b, 10H), 0.84 (m, 6H).
 

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