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Chemical Structure| 52157-62-7 Chemical Structure| 52157-62-7

Structure of 52157-62-7

Chemical Structure| 52157-62-7

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Product Details of [ 52157-62-7 ]

CAS No. :52157-62-7
Formula : C7H7BrO2S
M.W : 235.10
SMILES Code : BrC1=CC=C(C2OCCO2)S1
MDL No. :MFCD06209038

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Application In Synthesis of [ 52157-62-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52157-62-7 ]

[ 52157-62-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52157-62-7 ]
  • [ 79-22-1 ]
  • [ 67808-64-4 ]
YieldReaction ConditionsOperation in experiment
To a cooled [(-78C)] solution of [2- (5-BROMO-THIOPHEN-2-YL)- [1,] 3] dioxolane [(5.] 0g, [21. 3MMOL)] in tetrahydrofuran [(150ML)] was added n-butyl lithium (8. [52ML,] 21.3mmol, 2. 5M in hexanes) whilst keeping the temperature below [70C.] After 45 minutes [METHYLCHLOROFORMATE] (1. [65ML,] 21. [3MMOL)] in tetrahydrofuran [(5ML)] was added, and the reaction mixture was stirred for a further 4 hours. [1M] hydrochloric acid [(500ML)] was added and the resultant mixture was extracted with diethyl ether (2x [250ML).] The organic layers were combined, dried [(MGS04)] and concentrated to give an oil which was subjected to flash column chromatography on silica using a mixture of cyclohexane and ethyl acetate (4: 1, v/v) as eluent. The resulting fractions were concentrated and dissolved in 1,2- dimethoxyethane and water, to which concentrated sulphuric acid was added. After 1 hour the mixture was concentrated, to provide [5-FORMYL-THIOPHENE-2-CARBOXVLIC] acid methyl ester as a black solid, which was used in the next reaction without further purification.
 

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