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Chemical Structure| 52364-31-5 Chemical Structure| 52364-31-5

Structure of 52364-31-5

Chemical Structure| 52364-31-5

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Product Details of [ 52364-31-5 ]

CAS No. :52364-31-5
Formula : C13H13O4P
M.W : 264.21
SMILES Code : OCP(OC1=CC=CC=C1)(OC2=CC=CC=C2)=O

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Application In Synthesis of [ 52364-31-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52364-31-5 ]

[ 52364-31-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52364-31-5 ]
  • [ 38222-83-2 ]
  • trifluoromethane sulfonic anhydride [ No CAS ]
  • [ 124-38-9 ]
  • [ 115989-09-8 ]
YieldReaction ConditionsOperation in experiment
3.2 g (43%) In dichloromethane; acetone; For C13 H13 O4 P(0.2H2 O): A solution of trifluoromethane sulfonic anhydride (3.19 ml, 18.9 mmol) in methylene chloride (10 ml) was added dropwise to a dry ice/acetone cooled, mechanically stirred solution of <strong>[38222-83-2]2,6-di-tert-butyl-4-methylpyridine</strong> (4.28 g, 20.8 mmol) in methylene chloride (20 ml). The resulting slurry was warmed to -30 C. to effect solution, then was cooled to -78 C. while a solution of diphenyl hydroxymethylphosphonate (5.0 g, 18.9 mmol) in methylene chloride (10 ml) was added dropwise. This reaction mixture was slowly warmed to 0 C., affording a thick, white slurry which was filtered to remove the insoluble 2,6-di-tert-butyl-4-methylpyridinium triflate. The filtrate was diluted with methylene chloride and extracted with saturated aqueous sodium bicarbonate (100 ml), then was dried over magnesium sulfate, concentrated under vacuum, and chromatographed (silica gel eluted with 3:17 ethyl acetate/hexane) to afford 3.2 g (43%) of diphenyl (phosphonomethyl)trifluoromethyl sulfonate as a white solid (mp 71 C.-73 C.).
 

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