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Chemical Structure| 5266-72-8 Chemical Structure| 5266-72-8

Structure of 5266-72-8

Chemical Structure| 5266-72-8

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Product Details of [ 5266-72-8 ]

CAS No. :5266-72-8
Formula : C6H9N
M.W : 95.15
SMILES Code : N#CCCC1CC1
MDL No. :MFCD20484045

Safety of [ 5266-72-8 ]

Application In Synthesis of [ 5266-72-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5266-72-8 ]

[ 5266-72-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5266-72-8 ]
  • [ 2734-70-5 ]
  • 3-cyclopropyl-N-(2,6-dimethoxyphenyl)propanimidamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
0.35 g With trimethylaluminum; In hexane; toluene; at 0 - 110℃; To a mixture of Compound 4b (0.37 g, 3.9 mmol) and <strong>[2734-70-5]2,6-dimethoxyaniline</strong> (0.5 g, 3 mmol) in toluene (5 mL), at 0 C., was added a 2M solution of trimethylaluminum in hexane (2 ml, 4 mmol) dropwise. The reaction mixture was allowed to warm to room temperature and heated at 110 C. overnight. The reaction mixture was allowed to cool to RT and quenched with saturated aqueous Rochelle's salt and EtOAc. The phases were separated, the aqueous phase was extracted with EtOAc. The organic phases were combined and washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography eluting with 0 to 30% MeOH/0.5% TEA in DCM to give Compound 4c (0.35 g, 44% yield) as an orange oil. MS m/z=249.4 (M+H). 1H NMR (methanol-d4) δ 7.01 (t, J=8.3 Hz, 1H), 6.64 (d, J=8.3 Hz, 2H), 2.29-2.48 (m, 2H), 1.50-1.67 (m, 2H), 0.78-0.93 (m, 1H), 0.44 (s, 2H), 0.02-0.16 (m, 2H).
 

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