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Chemical Structure| 52663-90-8 Chemical Structure| 52663-90-8

Structure of 52663-90-8

Chemical Structure| 52663-90-8

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Product Details of [ 52663-90-8 ]

CAS No. :52663-90-8
Formula : C11H16N4O5
M.W : 284.27
SMILES Code : O=C(C1=NN([C@@H]2O[C@H](CO)[C@]3([H])[C@@]2([H])OC(C)(C)O3)C=N1)N

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Application In Synthesis of [ 52663-90-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52663-90-8 ]

[ 52663-90-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 58656-98-7 ]
  • [ 52663-90-8 ]
  • C22H28N4O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
6 g With caesium carbonate; In dimethyl sulfoxide; at 110℃; for 16h; 35.0 g of p-fluorobenzoic acid and 15.0 g of dimethylaminopyridine were dissolved in 500 mL of t-butanol and cooled to 0 C.107.50 g of di-tert-butyl dicarbonate was added to the mixture, followed by stirring at room temperature for 16 h.Purification by column chromatography to obtain a colorless oily product.The oily product was combined with 15.0 g of the intermediate product represented by formula (III).60.0 g of cesium carbonate was dissolved in 300 mL of dimethyl sulfoxide and heated continuously at 110 C for 16 h.Dimethyl sulfoxide was removed by distillation under reduced pressure. Add 200 mL of water to the residue.It was extracted with dichloromethane, dried over sodium sulfate and concentrated, and the residue was purified by column chromatography eluting with methanol/dichloromethane (50:1 by volume).The product of 6.0 g of a white solid was obtained at room temperature with hydrochloric acid/tetrahydrofuran (12 mol/L concentrated hydrochloric acid)A mixture of 10 ml and tetrahydrofuran (90 ml) was stirred for 16 h.The pH was adjusted to pH 9 with sodium bicarbonate and the mixture was filtered to give a crude material. The crude product was further crystallized three times with methanol to give 2.6 g of the pure product as a white solid, which was the ribavirin hapten of the formula (I), yield 55%. The specific synthetic route is shown in Figure 1.
  • 2
  • [ 58656-98-7 ]
  • [ 52663-90-8 ]
  • C15H16N4O7 [ No CAS ]
 

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