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Chemical Structure| 5280-10-4 Chemical Structure| 5280-10-4

Structure of 5280-10-4

Chemical Structure| 5280-10-4

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Product Details of [ 5280-10-4 ]

CAS No. :5280-10-4
Formula : C9H4F3N
M.W : 183.13
SMILES Code : FC1=C2N=CC=CC2=C(F)C(F)=C1
MDL No. :MFCD01939057

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Application In Synthesis of [ 5280-10-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5280-10-4 ]

[ 5280-10-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 367-34-0 ]
  • [ 56-81-5 ]
  • [ 5280-10-4 ]
YieldReaction ConditionsOperation in experiment
76% With sulfuric acid; sodium 3-nitrobenzenesulfonate sulfuric acid; In water; at 140℃; To the solution of concentrated sulfuric acid (18 mL) diluted with water (6 mL), was added <strong>[367-34-0]2,4,5-trifluoroaniline</strong> (3.68 g, 25 mmol), glycerol (4.60 g, 50 mmol) and sodium 3-nitrobenzenesulfonate (6.75 g, 30 mmol) in sequence. The resulting suspension was stirred at 140°C overnight. The reaction mixture was cooled to room temperature and added saturated NaHCC>3 aqueous solution to adjust pH to 7, extracted with dichloromethane (200 mL x 2). The combined organic layer was evaporated. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 3/1) to give the desired product (3.5 g, 76percent) as a yellow solid. H NMR (400 MHz, CDC13) delta 8.99 (s, IH), 8.46- 8.44 (m, IH), 7.61-7.56 (m, IH), 7.38-7.31 (m, IH).
 

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