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Chemical Structure| 52864-57-0 Chemical Structure| 52864-57-0

Structure of 52864-57-0

Chemical Structure| 52864-57-0

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Product Details of [ 52864-57-0 ]

CAS No. :52864-57-0
Formula : C8H8BrClO
M.W : 235.51
SMILES Code : ClC1=CC=C(CCO)C(Br)=C1
MDL No. :MFCD24130053

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 52864-57-0 ]

[ 52864-57-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52864-57-0 ]
  • [ 52927-98-7 ]
YieldReaction ConditionsOperation in experiment
77% With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20.0℃; for 2.0h; Step 1: 2-Bromo-l-(2-bromoethyl)-4-chlorobenzene [00342] 2-(2-bromo-4-chlorophenyl)ethanol ( 1.97 g, 8.36 mmol) and carbon tetrabromide (3.61 g, 10.9 mmol) were dissolved into DCM (30.0 mL, 468 mmol), then triphenylphosphine (3.29 g, 12.5 mmol) was added at rt. The reaction was stirred at rt for 2 hrs. To the reaction mixture was added 100 mL hexane with stirring, at which point a precipitate formed that was removed by filtration. The filtrate was concentrated and purified by flash column (80g column, 100% hexane as eluent) to provide 1.92g (77%) of the title compound. NMR (400 MHz, Chloroform-d) delta 7.55 - 7.41 (s, 1 H), 7.23 - 7.15 (d, J = 8.2 Hz, 1 H), 7.13 (d, J = 8.2 Hz, 1 H), 3.49 (t, J = 7.3 Hz, 2H), 3.18 (t, J = 7.3 Hz, 2H).
 

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